sleep Flashcards
0
Q
What structures contribute to the awake state?
A
hypothalamus, reticular activating system, and the basal forebrain: nucleus basalis of meynert
1
Q
What contributes to the awake state biochemically from the hypothalamus and what are the important locations?
A
histamine and glutamate in the posterior hypothalamus
hypocretin 1&2 made in the lateral hypothalamus and projecting broadly
2
Q
What are the important neurotransmitters of the reticular activating system, and the most important locations?
A
locus ceruleus
NE (and glutamate)
3
Q
What is the role of the basal forebrain and the nucleus basalis of Meynert in maintaining wakefulness, biochemically?
A
ACh goes to the cerebral cortex from the basal forebrain/nucleus basalis of Meynert. gets input from RAS
