SLE Flashcards
1
Q
define SLE?
A
multi-system inflammatory autoimmune disorder
2
Q
what kind of hypersensitivity is SLE?
A
• Type 3 hypersensitivity
3
Q
epidemiology of SLE?
A
- Presents in early adulthood
- More common in women
- More common in afro-Caribbean’s
4
Q
general symptoms of SLE?
A
o Fever o Fatigue o Weight loss o Mouth ulcers o Lymphadenopathy o Splenomegaly
5
Q
skin symptoms of SLE?
A
o Malar rash
o Raynaud’s phenomenon
o Discoid lupus (red scaly patches)
o Photosensitivity
6
Q
how might SLE affect musc?
A
arthritis
7
Q
how can SLE affect the heart?
A
pericarditis
8
Q
how can SLE affect the kidneys?
A
glomerulonephritis
9
Q
what might be seen on blood test?
A
o FBC – anaemia
o Raised ESR
o low levels of C3 and C4
10
Q
how is CRP in SLE?
A
CRP is normal
11
Q
which antibody has highest sensitivity?
A
ANA
12
Q
which antibody has highest specificity?
A
Anti-dsDNA
13
Q
what might be seen in urine?
A
protein
