SLE

Question 1

MC HLA

Answer 1

DRB1 0301 and 1501

Question 2

May cause SLE flare due to increase apoptosis in keratinocytes

Answer 2

UV light

Question 3

MC chronic dermatitis

Answer 3

Discoid lupus erythematosus

Question 4

Most serious manifestation of SLE

Answer 4

Nephritis

Question 5

Leading causes of mortality in the first decade of disease

Answer 5

Nephritis and Infections

Question 6

Indicators of dangerous proliferative glomerular damage

Answer 6

microscopic hematuria

proteinuria >500 mg/24h

Question 7

MC manifestation of diffuse CNS lupus

Answer 7

Cognitive Dysfunction

Question 8

GC induced psychosis

Answer 8

occurs in first week of GC therapy at doses > or equal to 40mg

Question 9

MC pulmo manifestation

Answer 9

Pleuritis +/- Pleural effusion

mild: NSAIDS
severe: GC

Question 10

Most frequent cardiac manifestation

Answer 10

Pericarditis infrequently with tamponade

Question 11

Pulmo manifestation of active SLE

Answer 11

Pulmonary infiltrates

Question 12

Most frequent hema manifestation

Answer 12

Normo, normo anemia

Question 13

Monitoring concerns for Initial IV therapy

Answer 13

Hyperglycemia
hypertension
osteoporosis
infection

Question 14

Indication for immunosuppressive therapies added to GC

Answer 14

Lupus Nephritis

Question 15

Worse prognosis of lupus nephritis

Answer 15

Crescentic Lupus Nephritis

Tx: High dose GC + High dose cyclophosphamide/mycophenolate

Question 16

Most frequent offender of drug-induced lupus

Answer 16

Procainamide and hydralazine

Question 17

Drug associated with risk of asceptic meningitis

Answer 17

NSAIDs