SLE Flashcards
1
Q
Active SLE (6)
A
- > 38
- Active urinary sediment
- Skin changes - alopecia, rash
- Mucosal membrane ulcers - PO/nasal
- Lymphadenopathy
- Tender joints
2
Q
Criteria (11)
A
- Malar rash (sparing NL folds)
- Discoid rash
- Photosensitive rash
- Oral ulcers
- Arthritis
- Serositis - pleurisy, pericarditis
- Renal disorder - proteinuria >0.5g
- Neurological - seizures/psychoses
- Haematological - haemolytic anaemia, pancytopenia
- Immunological - anti-ds DNA, anti-smith, AP (LAC, ACL, B2 glycoprotein)
- ANA
3
Q
History (13)
A
- Malaise, LOW, N+V, thombosis
- MSK - arthralgias, myalgias, myositis
- Dermatological - skin rash, alopecia, PO/nasal ulcers
- Fever
- Neuropsych Sx
- Renal tract Sx - haematuria, oedema, renal failure
- Resp tract Sx - pleurisy
- CVS - pericarditis, myocarditis, valvular lesions
- Haem - lymphadenopathy, anaemia
- GIT
- Recurrent miscarriages - APLS
- Sicca - dry eyes, mouth
- Decreased ADLs - ability to work
4
Q
Systems (9)
A
- Aphthous ulcers
- Serositis
- Raynaud’s
- Alopecia
- Photosensitive rashes
- Dry eyes, mouth
- Thrombosis
- Miscarriages
- Nephritis
5
Q
Causative meds (3)
A
- Hydralazine
- Anti-TNF
- Procainamide
6
Q
MCTD Ab
A
- UnRNP Antibody
7
Q
PBC Ab
A
- Anti-mitochondrial antibody
8
Q
Disease activity
A
- ds-DNA
- Low C3/C4
- ESR
9
Q
Management (6)
A
- NSAIDs
- Decrease exposure to sunlight - SUN-SMART
- HCQ - skin/jt manifestations - *retinal toxic
- Hypercoagulability - warfarin for life INR 2.5-3
- Lupus nephritis - MMF/steroids *4 types: mesangial, focal GN, diffuse prolif, membraneous prolif
