RA Flashcards
1
Q
Extra-articular manifestations (10)
A
- Skin - RP, ulcers
- Eyes - sicca, scleritis, episcleritis, cataracts (steroids)
- Sore throat, neck pain
- Lungs - ILD, pleural effusion
- Heart - pericarditis, VHD
- Renal - drug-use
- Nerves - peripheral neuropathy, mononeuritis multiplex, cord compression, entrapment neuropathy - CTS
- Blood - anaemia (dt chronic disease), IDA, folate deficiency, felty’s (splenomegaly, leukopenia)
- Systemic - fever, LOW, fatigue
- Vasculitis - PG
2
Q
Treatment (9)
A
- Aspirin - pain/nausea, gastric erosions, PUD
- NSAIDs - PUD, CVD, AKI
- MTx - hepatic, pulmonary, leukopenia, nil ETOH)
- LF - GIT, hepatic, alopecia
- Cyclosporin - renal, BP
- HCQ - Retinopathy
- Sulfasalazine - rash, nausea, haem, LFTs
- TNF-I - reactivate TB, ANA, lymphoma, demyelination
- Steroids
3
Q
Activity of disease (5)
A
- # of joints - active synovitis
- severity/duration of EMS
- functional ability
- changes in weight
- ESR, CRP
4
Q
O/E (10)
A
- Synovitis
- Steroid Cx
- Rheum nodules
- CVS - pericarditis
- Neuro
- Sicca
- Cataracts
- C-spine
- Abdo - splenomegaly
- Skin
5
Q
Anti-CCP
A
- Specific - severe and erosive disease
6
Q
XR (4)
A
- Joint space narrowing
- Marginal joint Erosions
- Soft tissue swelling
- Juxta-articular osteopenia
7
Q
Treatment Aim
A
- induce complete remission of the disease by suppressing the inflammatory process
8
Q
Non-pharm (4)
A
- Education
- PT - exercise/splinting of joints
- OT
- Smoking cessation
9
Q
RA monitoring (9):
A
- Disease activity
- Toxicity: bloods - is pt aware, adherent
- Wt/ETOH/smoking
- MTx, LF - FBE, UEC, LFT 3/12
- TNF - skin checks
- JAK-I: lipids. LFT, cytopenias
- HCQ: eye monitoring
- OP - BMD, falls, Ca/Vit D
- Septic episodes
- Vaccinations: Flu, COVID, strep, shingles
