Sarcoidosis

Question 1

What is it?

Answer 1

• Chronic, systemic, granulomatous disease
• Exaggerated T helper lymphocyte response –> granuloma formation and fibrosis

Question 2

Issues (8)

Answer 2

• Abnormal XR (30%)
• Fever, LOW, malaise, cough, dyspnoea (20%)
• Arthralgia + EN (20%)
• Eye - uveitis, sicca (10%)
• Palpable LN (5%)
• Hepatosplenomegaly
• Skin - lupus pernio (5%)
• Rare: cardiac arrhythmias, hypercalcaemia, CN palsies

Question 3

Investigations (7)

Answer 3

• Eosinophilia
• ACE
• ESR
• CXR - cavitation, aspergillus
• CT - GG, exclude TB
• RFT - ILD, decreased VC, decreased DLCO, normal FEV1/FVC ratio - can get mixed obstruction
• Biopsy via bronch