SLE

Question 1

Q. SLE is most common in……?

Answer 1

Young females

Question 2

A. What’s the best screening test for SLE?

Answer 2

Fluorescent test for ANA

Question 3

A. What’s the treatment for active SLE?

Answer 3

Corticosteroids, often hydroxychloroqione, sometimes immunosuppressant

Question 4

Q. Ptn who is on steroids for very long time because of SLE is in risk of developing what?

Answer 4

Osteonecrosis

Question 5

N. Ptn with SLE might have non-infectious endocarditis, what is it called?

Answer 5

Libman-Sacks endocarditis ( seen on mitral valve )

Question 6

N. C3, C4 are ⬆️ or ⬇️ in ptn with lupus?

Answer 6

⬇️ decreased

Question 7

N- All pregnant ptn with lupus should be screened for ,………. & ……..
- These antibodies cross placenta and transferred to the fetus causing neonatal lupus and heart block

Answer 7

SSA/ Anti-Ro antibodies

Question 8

N. Name the most important drugs that induce lupus? 4

Answer 8

Drug-induced lupus ( >40 drug can cause it ) but most important are:

• Hydralazine
• Isoniazid
• Procainamide
• Quinidine

Question 9

……………… antibody testing is sensitive marker for the diagnosis of drug induced lupus

Answer 9

Anti-histone

Question 10

N. Name the antibodies seen on SLE ? 3

Answer 10

ANA / Anti ds-DNA / Anti-sm