skull development (A11) Flashcards
1
Q
neonate
A
first 4 weeks of life
2
Q
intramembranous ossification
A
- mesenchymal cell differentiate into osteoblasts and begin to synthesize and secrete osteoid at multiple sites
- as cells become trapped they become osteocytes
- membrane bone formation from mesenchyme
- this process begins at particular sites called centres of ossification, these then grow outwards.
- the immature woven bone laid down initially will be remodeled to lamellar bone in time
3
Q
osteoblasts
A
lay down bone
4
Q
osteocytes
A
surrounded by bone
5
Q
location of start of intramembranous ossification
A
centres of ossification
6
Q
endochondral ossification/ bone formation
A
- mesenchyme -> chondroblasts
- embryo 5-6 weeks old- just hyaline cartilage
- embryo 6-8 weeks old- begins to develop periosteal/compact bone at secondary ossification centre
- featus 8-12 weeks- primary ossification centre develops along with blood vessels and cartilage begins to calcify?
7
Q
chondroblasts
A
lay down a cartilage model
8
Q
divisions of the neurocranium
A
- membranous neurocranium/dermatocranium
- cartilaginous neurocranium/chondrocranium
9
Q
dermatocranium
A
- membranous neurocranium
- flat bones of the skull eg. frontal and parietal bones
- formed by intramembranous ossification
10
Q
chondrocranium
A
- cartilaginous neurocranium
- bones of base of skull eg. ethmoid and sphenoid bones
- formed by endochondral ossification
11
Q
endochondral bone
A
- more supportive
- bones of the base of the skull (chondrocranium) eg. ethmoid and sphenoid bones
- support the brain above
- more complex shapes (general rule)
- long bones of the limbs
- under tight genetic control (achondroplasia)
12
Q
achondroplasia
A
- most common cause of dwarfism, or significantly abnormal short stature
- form of dwarfism
13
Q
membrane bone
A
- more protective
- flat bones of the membranous neurocranium eg. frontal and parietal bones
- the zygoma, maxilla and mandible of the viscerocranium
- mainly flat shapes (general rule)
- more easily modified by environmental factors (eg.hydrocephaly)
14
Q
hydrocephalus
A
a condition in which fluid accumulates in the brain, typically in young children, enlarging the head and sometimes causing brain damage
15
Q
hydrocephaly
A
- condition in which the brain grows within the cranial cavity, expanding rather like a balloon being inflated
- the increasing brain volume simply lifts the membrane bones of the neurocranium (frontal, parietal etc) apart, applying tension to the sutures between the bones and stimulating new bone formation at the sutural edges of the bones
- they grow more if the intracranial pressure rises, as in hydrocephaly (‘water on the brain’)
16
Q
skull growth rate (refer to diagram)
A
- driven by 4 factors (neural, dental, muscle, gonad)
- neurocranium dictated in utero by growth of brain (neural development is fast initially) 20% developed at birth
- brain has to be well enough developed at birth to enable protective reflexes (coughing) and suckling/swallowing
- neurocranium growth normally around 25% complete at birth
- > brain is fully developed around about the age of 7
- > dental development begins at 20% and increases steadily until the age of 2(40%) before plateauing, then increasing steadily to the age of 7 (60%) before gradually increasing, at age of 12 dental development is around 80% and by the age of around 20 reaches 100%
- > muscle and gonad development increasly slowly until the age of around 12 when gonad begins to steadily increase