Skin manifestations of systemic disease

Question 1

Endocrine:

Cushings:

• get it in pregnancy
• break/loss
• get it as a teenager

Answer 1

Striae
Atrophy
Acne

Question 2

Endocrine:

Addisons - found on hands

Answer 2

Pigmentation, especially in palmar creases and oral mucosa

Question 3

Endocrine:

Hyperthyroidism:

• legs
• hair
• temp of skin

Answer 3

Pretibial Myxoedema - pink/purple colour and thickening
Graves eye disease
Thyroid acropachy - overgrown nails +/- onycholysis
Hair thinning
Warm, flushed skin

Question 4

Endocrine:

Hypothyroidism:

• hair
• temp of skin
• texture of skin
• eyebrows
• happens around eyes and upper lip

Answer 4

Brittle scalp hair 
Cold, pale 
Dry skin 
Loss of outer eyebrows 
Periorbital and upper lip oedema - a form of myxoedema

Question 5

Metabolic disease:

Hyperlipidaemia

What disease do you find acanthuses nigricans in?

Answer 5

Hyperlipidaemia

DM

Question 6

Nutritional deficiencies:

Vitamin C deficiency:

• hair
• gums
• haemorrhaging

Answer 6

Corckscrew hair
Bleeding gums
Perifollicular haemorrhages

Question 7

Nutritional deficiencies:

Vitamin B3 deficiency:
-D3 in B3

Answer 7

Weeping dermatitis/eczema

Dementia
Diarrhoea