Skin infections (viral, fungi & mite) Flashcards

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1
Q

What does HSV stand for?

A

Herpes simplex virus !

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2
Q

What are the eight variants of human herpes viruses and what kind of viruses are they (DNA or RNA?)

A
HHV 1 - HSV type 1
HHV 2 - HSV type 2
HHV 3 - VZV
HHV 4 - EBV
HHV 5 - CMV
HHV 6 - Roseola virus 
HHV 7 - HHV 7 (same name)
HHV 8 - Kaposi Sarcoma 

DNA VIRUSES

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3
Q

Which cells do HSV type 1, 2 and varicella zoster virus target?

A

Mucoepithelial cells

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4
Q

Which two HHVs target lymphocytes and what are the other names for these viruses?

A

HHV 6 and HHV 8
HHV 6 - Roseola virus
HHV 8 - Kaposi Sarcoma

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5
Q

Which HHV targets B cells and what is its name?

A

EBV (HHV 4)

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6
Q

Which HHV targets T cells and what disease does it cause?

A

HHV 7 - causes Piryriasis rosea

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7
Q

Which HHV targets monocytes and epithelial cells and what diseases does it cause?

A

HHV 5 - CMV
Infectious mononucleosis like syndrome
Retinitis

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8
Q

What is the is the site of latency of EBV and KS?

A

B cells

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9
Q

What is the site of latency for CMV, roseola and HHV7?

A

Lymphocytes

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10
Q

What is the site of latency for HSV 1, 2 and VZV?

A

Neuron

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11
Q

What disease do HSV 1 and 2 cause?

A

Type 1 - oral herpes

Type 2 - genital herpes

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12
Q

What are the clinical presentations of type 1 and 2 herpes simplex viruses?

A

Vesicular rash (2w)
Eczema herpeticum
Herpes encephalitis

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13
Q

What do you call the first presentation of type 1 herpes and what does it look like?

A

Stomatitis - inflamed, reddish lips

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14
Q

How do you diagnose herpes simplex?

A

Take a swab and do PCR

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15
Q

What is the treatment for herpes simplex?

A

Acyclovir

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16
Q

What are the symptoms of varicella zoster virus?

A

Malaise
Fever
Sore throat
Vesicular rash

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17
Q

Where do the rashes concentrate in varicella?

A

Face - esp in mouth
Necks
Trunk

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18
Q

What can chicken pox cause in older people??

A

Pneumonia
Coma
Blindness
Chronic facial pain

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19
Q

What are the two types of superficial skin fungal infections?

A

Dermatophytes (fungi)

Yeasts (also fungi)

20
Q

What are dermatophytes attracted to and where do they common infect the skin?

A

Keratin e.g. in skin, hair and nails

21
Q

Where are yeasts attracted to and where do they common infect the skin?

A

Moist conditions e.g. body folds

22
Q

What do you call tinea infections of the nail?

A

Tinea unguium

23
Q

What do you call tinea infections of the scalp and who does this commonly affect?

A

Tinea capitis - PRE pubertal children

24
Q

What is the most common fungus which causes tinea unguium and capitis?

A

Trichophyton rubrum

25
Q

What do you call a localised mass of pustules on the scalp, caused by a fungal infection?

A

Kerion

26
Q

Who is most susceptible to kerions and widespread scalp fungal infections?

A

Afro-carribean children

27
Q

What is tinea manuum?

A

Fungal infections of the hands

28
Q

What typically causes tinea manuum?

A

Contact with pets who have fungal infections

29
Q

What do you call fungal infections of the foot?

A

Tinea pedis

30
Q

What do you call fungal infections of the groin?

A

Tinea cruris

31
Q

In men with tinea cruris, which part of their genitals is typically NOT affected?

A

Scrotum

32
Q

What do you call tinea of the face?

A

Tinea facei

33
Q

What do candida infections look like?

A

Red, inflamed, red dots surrounding the areas (satellite lesions)

34
Q

Name a common cause of yeast infections and what do you call it when this infects the skin?

A

Candida albicans; causes candida intertrigo

35
Q

How are fungal infections diagnosed?

A

Scrapings, clippings or pluckings of hair

Culture or PCR

36
Q

How do you treat fungal infections of the skin?

A

Terbinafine cream

37
Q

How do you treat fungal infections of the scalp and nails?

A

Terbinafine tablets

38
Q

Name two creams used to treat candida intertrigo

A

Clotrimazole (anti-yeast)

Canesten (also an antifungal)

39
Q

Name a mite that causes skin infections

A

Scabies

40
Q

What is another name for scabies?

A

Sarcoptes scabei

41
Q

How do scabies cause skin infections?

A

The female mite burrows into the stratum corneum of the epidermis

42
Q

Where are the sites of the burrows?

A

Finger webs
Toe webs
Around genital areas
Axillary

43
Q

How do these burrows appear?

A

4-5mm long squiggly line with a black dot at the end (the mite)

44
Q

What are the symptoms of scabies and their time frame?

A

Initially asymptomatic

After 4 weeks: immune reaction causing eczematous rash

45
Q

What is the treatment for scabies?

A

Permethrin insecticide cream
Ivermectin
tablet

46
Q

How is scabies transmitted?

A

Skin to skin contact (requires many minutes of contact to transmit the mite)

47
Q

What can develop secondary to untreated scabies? Give an example, its consequence and significance in the ‘third’ world?

A

Secondary bacterial infections e.g. streptococcus causing glomerulonephritis - most common cause of kidney failure in the third world!