Skin - Effect Of Environment On Skin Flashcards
Give reasons to why the skin is important
- The skin is a vital organ
- Normal adaptations of the skin to environmental pressures
- Abnormal effects of the environment such as:
- Physical damage to skin, nails and hair
- Ultraviolet damage: Burns, ageing and skin lesions
- Irritants, allergies and dermatitis
- Cutaneous infections
What is the integument?
- The interface between the body and the environment
- Thus subject to a wide range of insults
What May happen to the skin with extensive epidermal damage with severe burns? (Environmental insults on the skin)
Death May occur owing to one or more of
- Dehydration and shock
- Infection
- Heat loss and hypothermia
- Other factors such as protein loss, renal failure, electrolyte imbalance
State one type of fatal skin disease
- Toxic epidermal necrolysis: a rare adverse drug reaction
- Detachment of the epidermis
List the different environmental insults on the skin
- Irradiation & UV light
- Allergen
- Irritant
- Microbes, parasites
- Physical trauma (Burns, friction, pressure)
List some of the protective features of the skin
- Drying: Waterproof epidermis + oil from sebaceous glands
- Friction, impact: Thick regenerating epidermis, Nails
- Heat: Sweating, Vasodilation
- Cold: Subcutaneous fat, adaptable blood supply, hair
- Burns, Injury: Thick regenerating epidermis
- Radiation/sunlight: Thick epidermis, melanin
- Infections: Impervious epidermis
List some normal skin adaptations
- Sweating & Vasodilation in heat: Vasoconstriction in cold (Quite fast - Minutes)
- Tanning: Melanocyte response after ultraviolet exposure (Quite slow - Days)
- Hyperkeratosis: Thickening of stratum Corneum with rubbing or pressure after ultraviolet exposure (Quite slow - Days)
Describe how thermoregulation Is controlled by blood supply
- Arteriovenous (AV) shunts are anastomoses between arteriolars and venules
- Numerous in dermis
- Respond to thermoreceptors in the skin: Hot/Cold
When do the shunts open and close during thermoregulation of the blood supply
- Shunts open in response to decrease of blood flow to the superficial vascular plexus min the papillary dermis
- Shunts close in response to increase of blood flow to the superficial vascular plexus min the papillary dermis
- In face: Can also respond to emotion/sympathetic nervous system (blushing)
What happens if the arteriovenous shunts are shut off for too long?
Danger of damage (Frostbite’s May occur)
What is used to determine the colour of our skin?
- Dark skin is mainly due to melanin
- Light skin is mainly due to Haemoglobin
- There is a normal amount of genetic variation in the amount of melanin (<12 genes)
What does Melanin do in the skin?
- Protects against DNA damage and therefore against skin cancers
- Especially in dark (black & asiatic) skin
- Incidence is only 8-10% of that of white people
What happens during UV protection?
- The transfer of melanosomes (pigment granules) mainly to basal keratinocytes
What does Melanocytes do in terms of tanning?
- Melanocytes increase activity
- Make and transmit more Melanin
- Gives some protection against UV
- Additional protection by skin thickening in response to UV light
What is the process of suntanning?
Tyrosine -> L DOPA (via TYR) -> Dopaquinone (via TYR) -> either Eumelanins (brown to black) or Pheomelanins (yellow to red) via TRP’s
TYR = Tyrosinase TRPs = Tyrosine related proteins