skin and systemic disease Flashcards
Signs of GI hemorrage
- Hereditary hemorrhagic telangiectasia
- Blue rubber bled naevus
signs of IBD
Erythema nodusum
pyoderma gangrenosum
Signs of vitamin deficiency
Gum disease
Signs of diabetes
Acanthiosis nigricans Diabetic bullae Diabetic dermopathy Eruptive Xanthomas Necrobiosis lipoidica
Signs of hyperthyroid
Thyroid acropathy- swelling with overgrown nail beds
Hypothyroidism
Pretibial myxoedema
Signs of lupus
Butterfly rash
Alopecia areata
T-lymphcyte/ cytokine rejection of hair
What is the cause of vitiligo
destruction of melanocytes
What is carcinoid syndrome
- Episodic flushing
- No sweats
- Facial telangiectasia
- GI carcinoid has liver mets
- Brochial/ovarian could present without liver mets
What is ectopic ACTH
Tumour producing ACTH which leads to hyperpigmentation
ACTH release also increase melanocyte release
Paget’s disease sign
- Eczematous plaque usually around nipple or areola (pigmented area surrounded the nipple)
- Extension of underlying ductal adenoma
-Extra mammary pages- around the anus
Acquired hypertrichosis lagunosa
Acute onset of Laguno hairs on face and body
- Colorectal cancer> lung cancer> breast cancer
- Usually advanced
Erythema gyratum repens
Concentric erythematous lesions
Associated with lung cancer> oesophageal> breast cancer
Rarely associated with a pregnancy and mycobacterial infection
Bazes syndrome
Hyperkeratosis of extremities
Like psoriasis but will be negative on skin biopsy
Small cell caricoma : BRONCHIAL, OROPHARANGEAL, GASTRIC, COLON, BILIARY, ADENOCARCINOMAS
