Skin and Bone Flashcards

0
Q

Breslow Staging

A

Melanoma

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1
Q

Pebbly surface

A

Dysplastic Nevus

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2
Q
Coin-like
Stack-on appearanne
Lesser-Trelat Syn
Dermatosis Papulosa Nigra
Horn cyst
Invagination Cyst
A

Seborrheic Keratosis

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3
Q

Velvet-like texture

Undulation of dermal papillae

A

Acanthosis Nigricans

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4
Q

Cutaneous horn
Dyskeratosis
Elastosis
Parakeratosis

A

Actinic Keratosis

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5
Q

Keratoacanthoma is premalignant

A

Squamous cell carcinoma

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6
Q

Rodent ulcers
Telangiectasia

Multifocal growth
Nodular polyps
Palisading pattern

A

Basal Cell Carcinoma

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7
Q

Spongiosis

Intraepidermal Vesicles

A

Acute Eczematous Dermatitis

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8
Q
Target Lesions
Interface dermatitis
Targetoid lesions
SJS
TEN
A

Erythema multiforme

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9
Q
Test Tube in Rack Appearance
Samon-Colored Plaques
Koebnet Phenomenon
Auspitz Sign
Spongiform pustules of Kagoj
Munro Microabscesses
A

Psoriasis

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10
Q

Follocular Lipping

A

Dermatitis

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11
Q
Wickham Striae
Interface dermatitis
Saw toothing
Civatte or Colloid bodies
Lichen planopilaris
A

Lichen Planus

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12
Q
(+) Nikolsky Sign
Acantholysid
Suprabasal acantholytic blister
Subcorneal acantholytic blister
Netlike Immunofluorescense
A

Pemphigous

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13
Q

(-) Nikolsky Sign
Tense Bullae
Subepidermal nonacantholytic blister
Linear Immunofluorescence

A

Bullous pemphigoid

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14
Q

Slight rubbing of the skin results in exfoliation

A

(+) Nikolsky Sign

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15
Q

Urticaria and grouped vesicles

Asso with Celiac Disease

A

Dermatitis Herpetiformis

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16
Q

Microabscesses
Subepidermal blisters
Granular deposits of IgA

A

Dermatitis herpetiformis

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17
Q

IgA related diseases

A

Celiac Disease
HSP
Dermatitis Herpetiformis

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18
Q

Chronic inflammation of the pilosebaceous unit

A

Acne vulgaris

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19
Q

Keratin plug
Hypertrophy of Sebaceous Glands
Propionibacterium acnes
Follicular inflammation

A

Acne vulgaris (Comedogensis)

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20
Q

Papillomatous epidermal hyperplasia

Koilocytosis

A

Verrucae

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21
Q

Honey-colored crusts

A

Impetigo

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22
Q

Causes impetigo contagiosa

A

GABHS

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23
Q

Causes impetigo bullosa

A

S. aureus

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24
Q

Brittle bone disease
Blue sclerae
Hearing loss
Dental Imperfections

A

Osteogensis imperfecta

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25
Q

Marble bone disease
Albers-Schonberg disease
Erlenmeyer Flask deformity
Absence of medullary canal

A

Osteopetrosis

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26
Q

Mosaic, Jigsaw pattern
Leontiasis ossea
Platybasia
Chalkstick

A

Paget Disease

27
Q

Complications of Paget Disease of the bone

A

Osteosarcoma

High Output CHF

28
Q

Osteitis Fibrous Cystica
Von Recklinghausen disease of the bone
Dissecting osteitis
Brown Tumor

A

Hyperparathyroidism

29
Q

Avascular necrosis
Legg-Calve-Parthes Disease
Creeping substitution

A

Osteonecrosis

30
Q

Subperiosteal abscess
Involucrum
Brodie Abscess

A

Pyogenic Osteomyelitis

31
Q

Caused of Pyogenic Osteomyelitis

A

Staph aureus

Salmonella

32
Q

Nidus formation

A

Osteoid osteoma

33
Q

Lace-like pattern
Codman Triangles
Sunburst appearance

A

Osteosarcoma

34
Q

Most common bone cancer in children

A

Osteosarcoma

35
Q

Exostosis

A

Osteochondroma

36
Q

Chicken-wire pattern of mineralization

A

Chondroblastoma

37
Q

Anaplastic Chondrocytes

A

Chondrosarcoma

38
Q

McCune-Albright Syndrome
Precocious puberty
Cafe-au-lait spots
Chinese character looking bone

A

Fibrous dysplasia

39
Q

Homer-Wright Rosettes

A

Neuroblastoma
Medulloblastoma
Primitive Neuroectodermal Tumors
Ewing Sarcoma

40
Q

Flexner-Wintersteiner Rosette

A

Retinoblastoma

41
Q

True Ependymal Rosette

A

Endymoma

42
Q

aka Osteoclastoma

A

Giant Cell Tumor

43
Q

Osteoclastoma has mutations in what pathway?

A

RANK/RANKL signaling pathway

44
Q

Most common form of skeletal malignancy

A

Metastasis from Prostate

45
Q
Heberden Nodes (DIP)
Bouchard Nodes (PIP)
A

Osteoarthritis

46
Q

Mushroom-shaped outgrowths (osteophytes)
Joint mice
Eburnated articular surface

A

Osteoarthritis

47
Q

Benign bone-forming tumors < 2 cm?

> 2 cm?

A

Osteoid osteoma < 2 cm

Osteoblastoma > 2 cm

48
Q

Ewing Sarcoma has mutations in what gene and chromosome?

A

EWS gene in Chromosome 22

49
Q

Dislodged pieces of cartilage and subchondral bone

A

Joint Mice

50
Q

Chronic systemic inflammatory disorder that may affect many tissues and organs
Non-suppurative proliferative and inflammatory synovitis

A

Rheumatoid Arthritis

51
Q

Antibodies implicated in Rheumatoid Arthritis

A

RF and anti-CCP

52
Q

PANNUS formation
Obliterative endarteritis
Joint effusions and juxta-articular osteopenia with erosions
Rheumatoid nodules

A

Rheumatoid Arthritis

53
Q

HLA-B27

Bamboo Spine Deformity

A

Ankylosing Spondylitis

54
Q

aka Reactive Arthritis

A

Reiter’s Syndrome

55
Q

What infections may trigger Reactive Arthritis?

A
Shigella
Salmonella
Yersinia
Campylobacter
Chlamydia
56
Q

Reiter’s Triad?

A

Urethritis
Uveitis
Arthritis

57
Q

Achilles tendon periositis
BALANTIS CIRCINATA
KERATODERMA BLENORRHAGICA

A

Reiter’s Syndrome

58
Q

Serpiginous annular dermatitis of the gland penis

A

Balanitis circinata

59
Q

Vesico-pustular waxy lesion with a yellow brown color found in the palms and soles

A

Keratoderma blenorrhagica of Reiter’s Syndrome

60
Q

Sausage-shaped DIP joints of finger or toe
Pencil-cup deformity in xray
Extensive nail pitting

A

Psoriatic Arthritis

61
Q

Negatively bifringent monosodium urate crystals

A

Gout

62
Q

Large aggregations of urate crystals surrounded by intense inflammatory reaction

A

Tophi

63
Q

Deposition of MSU crystals in the renal medullary interstitium

A

Gouty Nephropathy

64
Q

aka Calcium Pyrophosphate Crystal Deposition Disease (CPPD)

or Chondrocalcinosis

A

Pseudogout

65
Q

Caused by mutations in the ANKH gene
(+) birefringent CPP crystals
Chalky-white friable deposits

A

Pseudogout