Skin and Bone

Question 0

Breslow Staging

Answer 0

Melanoma

Question 1

Pebbly surface

Answer 1

Dysplastic Nevus

Question 2

Coin-like
Stack-on appearanne
Lesser-Trelat Syn
Dermatosis Papulosa Nigra
Horn cyst
Invagination Cyst

Answer 2

Seborrheic Keratosis

Question 3

Velvet-like texture

Undulation of dermal papillae

Answer 3

Acanthosis Nigricans

Question 4

Cutaneous horn
Dyskeratosis
Elastosis
Parakeratosis

Answer 4

Actinic Keratosis

Question 5

Keratoacanthoma is premalignant

Answer 5

Squamous cell carcinoma

Question 6

Rodent ulcers
Telangiectasia

Multifocal growth
Nodular polyps
Palisading pattern

Answer 6

Basal Cell Carcinoma

Question 7

Spongiosis

Intraepidermal Vesicles

Answer 7

Acute Eczematous Dermatitis

Question 8

Target Lesions
Interface dermatitis
Targetoid lesions
SJS
TEN

Answer 8

Erythema multiforme

Question 9

Test Tube in Rack Appearance
Samon-Colored Plaques
Koebnet Phenomenon
Auspitz Sign
Spongiform pustules of Kagoj
Munro Microabscesses

Answer 9

Psoriasis

Question 10

Follocular Lipping

Answer 10

Dermatitis

Question 11

Wickham Striae
Interface dermatitis
Saw toothing
Civatte or Colloid bodies
Lichen planopilaris

Answer 11

Lichen Planus

Question 12

(+) Nikolsky Sign
Acantholysid
Suprabasal acantholytic blister
Subcorneal acantholytic blister
Netlike Immunofluorescense

Answer 12

Pemphigous

Question 13

(-) Nikolsky Sign
Tense Bullae
Subepidermal nonacantholytic blister
Linear Immunofluorescence

Answer 13

Bullous pemphigoid

Question 14

Slight rubbing of the skin results in exfoliation

Answer 14

(+) Nikolsky Sign

Question 15

Urticaria and grouped vesicles

Asso with Celiac Disease

Answer 15

Dermatitis Herpetiformis

Question 16

Microabscesses
Subepidermal blisters
Granular deposits of IgA

Answer 16

Dermatitis herpetiformis

Question 17

IgA related diseases

Answer 17

Celiac Disease
HSP
Dermatitis Herpetiformis

Question 18

Chronic inflammation of the pilosebaceous unit

Answer 18

Acne vulgaris

Question 19

Keratin plug
Hypertrophy of Sebaceous Glands
Propionibacterium acnes
Follicular inflammation

Answer 19

Acne vulgaris (Comedogensis)

Question 20

Papillomatous epidermal hyperplasia

Koilocytosis

Answer 20

Verrucae

Question 21

Honey-colored crusts

Answer 21

Impetigo

Question 22

Causes impetigo contagiosa

Answer 22

GABHS

Question 23

Causes impetigo bullosa

Answer 23

S. aureus

Question 24

Brittle bone disease Blue sclerae Hearing loss Dental Imperfections

Answer 24

Osteogensis imperfecta

Question 25

Marble bone disease Albers-Schonberg disease Erlenmeyer Flask deformity Absence of medullary canal

Answer 25

Osteopetrosis

Question 26

Mosaic, Jigsaw pattern Leontiasis ossea Platybasia Chalkstick

Answer 26

Paget Disease

Question 27

Complications of Paget Disease of the bone

Answer 27

Osteosarcoma | High Output CHF

Question 28

Osteitis Fibrous Cystica Von Recklinghausen disease of the bone Dissecting osteitis Brown Tumor

Answer 28

Hyperparathyroidism

Question 29

Avascular necrosis Legg-Calve-Parthes Disease Creeping substitution

Answer 29

Osteonecrosis

Question 30

Subperiosteal abscess Involucrum Brodie Abscess

Answer 30

Pyogenic Osteomyelitis

Question 31

Caused of Pyogenic Osteomyelitis

Answer 31

Staph aureus | Salmonella

Question 32

Nidus formation

Answer 32

Osteoid osteoma

Question 33

Lace-like pattern Codman Triangles Sunburst appearance

Answer 33

Osteosarcoma

Question 34

Most common bone cancer in children

Answer 34

Osteosarcoma

Question 35

Exostosis

Answer 35

Osteochondroma

Question 36

Chicken-wire pattern of mineralization

Answer 36

Chondroblastoma

Question 37

Anaplastic Chondrocytes

Answer 37

Chondrosarcoma

Question 38

McCune-Albright Syndrome Precocious puberty Cafe-au-lait spots Chinese character looking bone

Answer 38

Fibrous dysplasia

Question 39

Homer-Wright Rosettes

Answer 39

Neuroblastoma Medulloblastoma Primitive Neuroectodermal Tumors Ewing Sarcoma

Question 40

Flexner-Wintersteiner Rosette

Answer 40

Retinoblastoma

Question 41

True Ependymal Rosette

Answer 41

Endymoma

Question 42

aka Osteoclastoma

Answer 42

Giant Cell Tumor

Question 43

Osteoclastoma has mutations in what pathway?

Answer 43

RANK/RANKL signaling pathway

Question 44

Most common form of skeletal malignancy

Answer 44

Metastasis from Prostate

Question 45

``` Heberden Nodes (DIP) Bouchard Nodes (PIP) ```

Answer 45

Osteoarthritis

Question 46

Mushroom-shaped outgrowths (osteophytes) Joint mice Eburnated articular surface

Answer 46

Osteoarthritis

Question 47

Benign bone-forming tumors < 2 cm? | > 2 cm?

Answer 47

Osteoid osteoma < 2 cm | Osteoblastoma > 2 cm

Question 48

Ewing Sarcoma has mutations in what gene and chromosome?

Answer 48

EWS gene in Chromosome 22

Question 49

Dislodged pieces of cartilage and subchondral bone

Answer 49

Joint Mice

Question 50

Chronic systemic inflammatory disorder that may affect many tissues and organs Non-suppurative proliferative and inflammatory synovitis

Answer 50

Rheumatoid Arthritis

Question 51

Antibodies implicated in Rheumatoid Arthritis

Answer 51

RF and anti-CCP

Question 52

PANNUS formation Obliterative endarteritis Joint effusions and juxta-articular osteopenia with erosions Rheumatoid nodules

Answer 52

Rheumatoid Arthritis

Question 53

HLA-B27 | Bamboo Spine Deformity

Answer 53

Ankylosing Spondylitis

Question 54

aka Reactive Arthritis

Answer 54

Reiter's Syndrome

Question 55

What infections may trigger Reactive Arthritis?

Answer 55

``` Shigella Salmonella Yersinia Campylobacter Chlamydia ```

Question 56

Reiter's Triad?

Answer 56

Urethritis Uveitis Arthritis

Question 57

Achilles tendon periositis BALANTIS CIRCINATA KERATODERMA BLENORRHAGICA

Answer 57

Reiter's Syndrome

Question 58

Serpiginous annular dermatitis of the gland penis

Answer 58

Balanitis circinata

Question 59

Vesico-pustular waxy lesion with a yellow brown color found in the palms and soles

Answer 59

Keratoderma blenorrhagica of Reiter's Syndrome

Question 60

Sausage-shaped DIP joints of finger or toe Pencil-cup deformity in xray Extensive nail pitting

Answer 60

Psoriatic Arthritis

Question 61

Negatively bifringent monosodium urate crystals

Answer 61

Gout

Question 62

Large aggregations of urate crystals surrounded by intense inflammatory reaction

Answer 62

Tophi

Question 63

Deposition of MSU crystals in the renal medullary interstitium

Answer 63

Gouty Nephropathy

Question 64

aka Calcium Pyrophosphate Crystal Deposition Disease (CPPD) | or Chondrocalcinosis

Answer 64

Pseudogout

Question 65

Caused by mutations in the ANKH gene (+) birefringent CPP crystals Chalky-white friable deposits

Answer 65

Pseudogout