Skin Flashcards
Scalp lesion
Aplasia Cutis Congenita
- congenital absence of skin
- single or multiple, usually scalp involved
Young child with short, deformed right arm and large, red, scaly skin patches
CHILD syndrome
congenital hemidysplasia with ichthyosiform erythroderma
What is this?
Ichthyosis:
Thickened lamellar hyperkeratosis, reduced/absent granular layer
What is this?
Fetal Harlequin Ichthyosis
Infant encased in keratinous membrane sheds in 1-2 weeks
Collodion Baby
17 yo w/vesicles in neck, groin & axillae
Hailey-Hailey disease
What is this?
Restrictive dermopathy
Histology: thick, hyperkeratotic epidermis, flat rete-ridges, poorly developed adnexal structures
What are features of focal dermal hypoplasia
Thin dermis w/ thin fibrils of collagen admixed with fat
X-linked dominant
A neonate with diffuse skin blistering, respiratory failure and GI bleeding
Epidermolysis bullosa, junctional type - note cleavage above basement membrane
Child with vesiculobullous acral and perioral lesions, diarrhea and alopecia
Acrodermatitis enteropathica - intraepidermal vesicles with psorisiform hyperplasia
Granular IgA at tips of dermal papillae
vs
Linear IgA at basement membrane
Dermatitis herpetiformis - gluten, scalp & extensor surfaces
vs
Linear IgA bullous dermatosis - no gluten ass’n; tense bullae lower trunk
Both w/bullae containing neutrophils & eos
Erythema toxicum neonatorum
Eosinophils in pilosebacceous units
Self-limited macular-pustular rash
Name 2 transient dermatoses in black infants/neonates
Acropustulosis of infancy
Transient neonatal pustular melanosis
Pustules in both contain neutrophils
Most common skin infection in children
Impetigo (staph aureus)
Dermatitis caused by Group A strep
Ecthyma - ulcerative dermatitis w/dense neutrophils
Cutaneous ulcers w/ scant neutrophils in an immunecompromised child
Ecthyma gangrenosum - pseudomonas; necrotizing vasculitis at base of ulcers
Continuous granular deposits of IgG & C3 at DE junction
Lupus erythematousus
Syndrome: multiple epidermal inclusion cysts
Gardner
What is this?
Steatocystoma: note corrugated epithelium and sebaceous units
What is this?
Myofibroma/myofibromatosis
- note central hemangiopericytoma-like pattern and peripheral celular proliferation of fibroblasts/myofibroblasts
Negative for virus. What is this?
Urticaria pigmentosa - diffuse mast cell induced maculaopapular rash
What is Darier sign?
Marked focal redness over area of trauma/scratching 2* degranulation of mast cells in systemic mastocytosis
Name the tumors most commonly associated with this presentation
Blueberry muffin baby:
Neuroblastoma, leukemia, choriocarcinoma, rhabdomyosarcoma
Name the dermal manifestations of tuberous sclerosis
Ashleaf spot, angiofibroma, fibroma, shagreen patch
