1st & 2nd Trimester Loss

Question 1

What are 4 types of growth disorganized embryo

Answer 1

1. GDI: Intact, empty amniotic sac
2. GDII: Nodular embryo - no obvious cranial vs caudal end
3. GDIII: Cylindrical embryo w/some cranio-caudal & eye pigment
4. GDIV: Less malformed w/delayed growth of limbs

Question 2

What is most common cause of 1st trimester abortion?

Answer 2

Lethal chromosomal abnormalities, usually aneuploidy.

Question 3

What is this?

Answer 3

GD embryo Type I

Question 4

What is this?

Answer 4

GD embryo Type II

Question 5

What is this?

Answer 5

GD embryo Type III

Question 6

What is this?

Answer 6

GD embryo Type IV

Question 7

Which fetal aneuploidy type is most likely to show abnormal villous formation?

Answer 7

Trisomy 22

Question 8

What percent of complete hydatiform moles require chemotherapy?

Answer 8

15-28%

Question 9

What are two maternal mediated causes/histologic features in spontaneous abortion of the 1st trimester

Answer 9

Chronic intervillousitis

&

Increased perivillous fibrin deposition

Question 10

What bacterial species can cause first trimester pregnancy loss, as well as second and third?

Answer 10

Listeria

Question 11

What are the placental features of Listeriosis?

Answer 11

Acute neutrophilic villitis with intervillous abscesses.

Question 12

What is the chromosomal pattern of complete hydatiform mole?

Answer 12

YY

Question 13

What is the most likely chromosomal pattern of a partial mole in a missed abortion with grossly cystic villi?

Answer 13

XYY (diandric)

Question 14

What disease is the most likely cause of necrotizing funisitis?

Answer 14

Syphillis

Question 15

What is the most common cause of peripheral funisitis?

Answer 15

Candida

Question 17

What are the microscopic characteristics of a partial mole?

Answer 17

DIMORPHIC population of large and small villi without intermediate forms, irregular villous contours often with MULTICELLULAR TROPHOBLAST INCLUSIONS within villous stroma