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IHO Week 6 > Skildog HIV > Flashcards

Skildog HIV Flashcards

0
Q

Capsid symmetry for HIV?

A

Icosahedral

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1
Q

Genome classification for HIV?

A

2 copies of + sense RNA

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2
Q

Enveloped?

A

Yes

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3
Q

What two envelope proteins are important for viral recognition?

A

gp41 and gp120

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4
Q

What is the tropism for HIV?

A

CD4+ T cells
Macrophages
Monocytes

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5
Q

What gene encodes the capsid?

A

Gag

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6
Q

What protein spikes early on in infection?

A

p24

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7
Q

What gene encodes for gp120 and gp41?

A

Env

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8
Q

____ is the glycoprotein that is not connected to the membrane on its own, but rather via ____ glycoprotein.

A

gp120, gp41

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9
Q

What two receptors are important for viral entry into T cells?

A 
CD4 
Chemokine receptors (CXCR4, CCR5)
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10
Q

What protein binds to CXCR4 to prevent viral entry into the cell?

A

SDF-1 (stromal derived factor)

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11
Q

What are the two functions of viral reverse transcriptase?

A

Make a ssDNA copy of viral RNA

Make dsDNA from ssDNA

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12
Q

What enzyme is responsible for the formation of a provirus from the viral dsDNA?

A

Integrase

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13
Q

What is the role of Tat?

A

Creates spliced RNA from genome (Replication machinery)

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14
Q

What is the role of Rev?

A

Creates all of the products that will be incorporated into the final virus particle

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15
Q

What is the role of Nef?

A

Promotes budding of virus out of T cell

16
Q

What important protein for recognition is encoded by Gag?

A

p24

17
Q

What three important proteins are encoded by Pol?

A

Reverse transcriptase, protease, integrase

18
Q

What are LTR’s

A

Integration sites important for incorporation into genome,

Strong promoters of transcription

19
Q

What two testing techniques are used for monitoring HIV progress in patients?

A

CD4+ count via flow cytometry

PCR of vDNA or vRNA

IHO Week 6 (8 decks)

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