Inflammatory Drugs Flashcards
PGE2 and PGI2 cause:
vasodilation, vascular permeability increase, pain
Histamine causes these 4 things, but not this one thing.
Redness, heat, swelling, airway constriction
Not chemotaxis
PGD2 and thromboxane cause:
Bronchoconstriction
TXA2 causes:
Platelet aggregation and vasoconstriction
PGI2 causes:
Platelet aggregation and vasodilation
LTB4 casues:
chemotaxis of PMN’s and pain threshold reduction
Kinins cause:
Everything, potent vasodilator. Not major chemotaxis agent
H1 receptor binding causes: (5)
Bronchoconstriction Decreased gastric motility Increased vascular permeability Pruritis and pain increased catacholamine release from adrenal medulla
H2 receptor stimulation results in:
Gastric acid secretion
IgE mediated basophil histamine release
Inhibition of T cell mediated cytotoxicity
Suppression of Th2 and cytokines
Major side effects of H1 antihistamines
sedation
drying of mucousal secretions
GI disturbances
What are the two H1 antagonists we’re supposed to know?
Diphenhydramine
Chorpheniramine
What are the second generation antihistamines?
Cetirizine
Fexofenadine
Loratadine
Why do second gen antihistamines not have CNS effects?
Affinity for p-glycoprotein pump
No affinity for acetylcholine receptors
What are the nonspecific NSAIDs?
Sulindac Ketorolac Ibuprofen Naproxen Piroxicam Indomethacin Ketoprofen
What is the specific COX2 inhibitor we need to know?
Celecoxib
Acetaminophen works how:
Antipyretic, analgesic
NOT Anti-inflammatory
What is the method of action of zileuton?
Prevents synthesis of LTB4
What is the method of action of Zafirlukast and Montelukast
Leukotriene receptor antagonists
Why isn’t Zafirleukast used as much?
Inhibits a P450 enzyme, resulting in cross reactions
