Autoimmunity Flashcards
Where does central tolerance take place?
Central lymphoid organs (bone marrow, thymus)
Peripheral self-tolerance is mediated by what?
Treg cells
What gene class deficiency has the highest correlation to autoimmunity diseases?
HLA
Patients with SLE can oftentimes have antibodies against _____, resulting in these test abnormalities.
Phospholipids,
Syphilis and PTT
The fundamental defect in SLE is what failure?
Mechanisms to maintain self tolerance
What is SOAP BRAIN MD? What do the letters stand for?
Mnemonic for diagnosing Lupus
Serousitis, Oral ulcers, Arthritis, Photosensitivity
Blood, Renal, Antinuclear antibodies, I for other characteristic antibodies, Neurologic
MD For characteristic rash on face
What cells are responsible for problems in rheumatoid arthritis?
CD4+ T cells
Sjogren syndrome is characterized by what pathology?
Autoimmune destruction of tear and salivary glands
Scleroderma is linked to antibodies attacking what enzyme?
Topoisomerase I, centromeres
What cells are indicated to be the problem in scleroderma?
CD4+
What problems are associated with scleroderma? Lungs: GI: Skin: Musculoskeletal: Kidneys:
Lungs: Interstitial fibrosis
GI: Dysmotility, reflux, malabsorption, cramps, diarrhea
Skin: Raynaud’s, sclerosis, dystrophic calcification
Musculoskeletal: Arthritis
Kidneys: vascular thickening resulting in hypertension
Dermatomyositis is thought to be due to the destruction of what?
Capillaries and small vessels in muscles
As well as T lymphocyte activation
Cyclic citrullinated antibodies are responsible for what disease?
RA
Ribosome P antibodies are indicative of:
SLE
Centromere antibodies are indicative of:
CREST syndrome
SSa/Ro antibodies are indicative of:
Sjogren syndrome
SS-B/LA antibodies are indicative of:
Sjogren syndrome
Sm antibodies are indicative of:
SLE
RNP antibodies are indicative of:
Mixed connective tissue disease
Scl70 antibodies are indicative of:
Scleroderma
Jo 1 antibodies are indicative of:
Polymyositis
dsDNA antibodies are indicative of:
SLE
