Sketchy Adrenergic Flashcards
Mime and Bear
Sympathomimetic
QISS
a1-Gq ; a2-Gi ; B1-Gs ; B2-Gs
Alpha scout
Alpha receptor agonists
Single-lit candle
alpha-1 agonist
3 dags
alpha-1 receptor coupled to Gq - IP3/DAG cascade
Dag with bone
IP3/DAG cascade leads to increased intracellular Ca (smooth muscle cell)
red leashes pulled tight
alpha-1 activation increases peripheral arterial resistance - vasoconstriction at small arteries, arterioles, precapillary sphincters
Alpha-1 scout elevating MAP
alpha-1 activation increases MAP
blue leashes pulled tight
alpha-1 activation increases venous return (venoconstriction) - useful when treating hypovolemic/distributive shock
Alpha-1 scout binoculars
alpha-1 activation at pupillary dilator muscle causes mydriasis
Alpha-1 scout pulling drawstring
alpha-1 activation causes urethral sphincter and prostatic smooth muscle contraction
Full bladder canteen
alpha-1 activation causes urinary retention
Two lit candles
alpha-2 agonist
“No Sympathy”
alpha-2 agonists are sympatholytics - act centrally to decrease sympathetic tone
Packed up alpha-2 camp tent
alpha-2 receptor coupled to Gi - decreased cAMP
Alpha-2 scout packing up presynaptic wire
presynaptic alpha-2 receptors cause inhibition of NT release
Rolled up Welcome Inside mat
alpha-2 activation at pancreatic islet cells decreases insulin release
Alpha-2 scout dousing roasting pig
alpha-2 activation inhibits lipolysis and release of fatty acids
Alpha-2 scout emptying water from eyeball hat
alpha-2 activation at ciliary body decreases aqueous humor production
Brim of eyeball hat
Brimonidine - alpha-2 agonist used to treat chronic open angle glaucoma - decrease aqueous humor production
Band camp
beta receptor agonists increase cAMP
Beta-1 bugle
Beta-1 agonist
I
beta-1 receptors found on cardiac myocytes (SA/AV node); increased cAMP = increased Ca
Elevated heart clock
beta-1 activation increases heart rate (SA node)
Buff bicep
beta-1 activation increases cardiac contractility (myocytes)
Heart hydrant
beta-1 activation results in increased CO
Open rain umbrella
beta-1 activation increases renin release
Beta-2 tuba
beta-2 activity
Beta-2 camper taking big breath
beta-2 activation leads to broncho-dilation; increased cAMP = activates PKA
Beta-2 camper with dilated sleeves
Beta-2 activation causes coronary and skeletal muscle vasodilation - decreases TPR
Beta-2 camper with dangling DIAmond earrings
beta-2 activation decreases diastolic blood pressure
Beta-2 camper roasting pig
beta-2 activation stimulates lipolysis and release of FFA
Beta-2 camper producing marshmallows from liver-shaped bag
beta-2 activation at liver promotes gluconeogenesis
Welcome Inside mat
Beta-2 activation at pancreatic islet cells promotes insulin release
Banana peels
beta-2 activation can cause hypokalemia due to increased insulin
Beta-2 camper filling eyeball balloon
beta-2 activation at ciliary body increases aqueous humor production
Flannel friends
phenylephrine - alpha-1 agonist
Flannel friends nasal spray
phenylephrine treats nasal congestion - alpha-1 mediated vasoconstriction
Flannel friends binoculars
phenylephrine causes mydriasis - activates alpha-1 at pupillary dilator muscle
Flannel friends elevated MAP
Phenylephrine increases MAP - alpha-1 increase in TPR; increases SBP/DBP - used in shock
Flannel friends dangling heart watch
phenylephrine causes reflex bradycardia
North Compass
Norepinephrine - alpha1>beta1 agonist
North Scout blowing beta-1 bugle
NE has some beta-1 activity but primarily alpha agonist
North Scout elevated MAP
NE increases MAP, SBP, DBP
North Scout dangling heart watch
NE causes reflex bradycardia
North Scout buff contracted bicep
NE increases contractility through activation of beta-1
Septic tank
septic shock - phenylephrine and NE increase TPR and venous return to treat distributive/hypovolemic shock
Just DO BUgling shirt
Dobutamine (beta1 > beta2)
Just DO BUgling winding up heart flashlight
Dobutamine increases HR, contractility, CO
Just DO BUgling friend’s beta-2 tuba
Dobutamine has beta-2 activity
Just DO BUgling MAP
Dobutamine increases pulse pressure, increases SBP, decreases DBP
Batteries out of heart flashlight
Dobutamine can be used in cardiogenic shock
Iso-pro-tunnel between beta-1/beta-2 camps
isoproterenol - beta1/beta2 agonist
Tunnel camper’s elevated heart watch/contracted bicep
Isoproterenol increases HR and contractility
Tunnel camper’s dilated sleeves
isoproterenol causes vasodilation - decreases TPR
Tunnel camper’s dangling DIAmond earrings
isoproterenol decreases diastolic pressure
Tunnel between tents
Isoproterenol decreases MAP, decreases diastolic pressure which increases Pulse pressure
Sleeping beta-2 counselor
beta-2 agonists relax uterine smooth muscle
Do not disTURB
terbutaline prevents premature labor - relaxes uterus
I dream of band camp
Ritodrine prevents premature labor - relaxes uterus
Rol call sheet
beta-2 agonists used for bronchodilation have “rol” suffix
Epic kiss between alpha/beta camps
Epinephrine - beta > alpha agonist
Low side of Epic raft
Low doses - epinephrine’s beta agonist effects predominate
Beta-2 tuba girl’s epic inhaler
epinephrine causes bronchodilation (beta-2)
Epic diamond falling off low side of raft
low doses, epinephrine decreases diastolic pressure
Epic elevated heart watch and buff bicep
epinephrine increases HR/contractility (beta-1)
High side of raft
High doses of epinephrine, alpha agonist effects predominate
High side MAP
Epinephrine increases systolic pressure, decrease diastolic pressure, increase MAP and increase pulse pressure