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Pharm 1 > Sketchy Adrenergic > Flashcards

Sketchy Adrenergic Flashcards

1
Q

Mime and Bear

A

Sympathomimetic

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2
Q

QISS

A

a1-Gq ; a2-Gi ; B1-Gs ; B2-Gs

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3
Q

Alpha scout

A

Alpha receptor agonists

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4
Q

Single-lit candle

A

alpha-1 agonist

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5
Q

3 dags

A

alpha-1 receptor coupled to Gq - IP3/DAG cascade

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6
Q

Dag with bone

A

IP3/DAG cascade leads to increased intracellular Ca (smooth muscle cell)

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7
Q

red leashes pulled tight

A

alpha-1 activation increases peripheral arterial resistance - vasoconstriction at small arteries, arterioles, precapillary sphincters

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8
Q

Alpha-1 scout elevating MAP

A

alpha-1 activation increases MAP

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9
Q

blue leashes pulled tight

A

alpha-1 activation increases venous return (venoconstriction) - useful when treating hypovolemic/distributive shock

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10
Q

Alpha-1 scout binoculars

A

alpha-1 activation at pupillary dilator muscle causes mydriasis

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11
Q

Alpha-1 scout pulling drawstring

A

alpha-1 activation causes urethral sphincter and prostatic smooth muscle contraction

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12
Q

Full bladder canteen

A

alpha-1 activation causes urinary retention

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13
Q

Two lit candles

A

alpha-2 agonist

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14
Q

“No Sympathy”

A

alpha-2 agonists are sympatholytics - act centrally to decrease sympathetic tone

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15
Q

Packed up alpha-2 camp tent

A

alpha-2 receptor coupled to Gi - decreased cAMP

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16
Q

Alpha-2 scout packing up presynaptic wire

A

presynaptic alpha-2 receptors cause inhibition of NT release

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17
Q

Rolled up Welcome Inside mat

A

alpha-2 activation at pancreatic islet cells decreases insulin release

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18
Q

Alpha-2 scout dousing roasting pig

A

alpha-2 activation inhibits lipolysis and release of fatty acids

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19
Q

Alpha-2 scout emptying water from eyeball hat

A

alpha-2 activation at ciliary body decreases aqueous humor production

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20
Q

Brim of eyeball hat

A

Brimonidine - alpha-2 agonist used to treat chronic open angle glaucoma - decrease aqueous humor production

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21
Q

Band camp

A

beta receptor agonists increase cAMP

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22
Q

Beta-1 bugle

A

Beta-1 agonist

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23
Q

I

A

beta-1 receptors found on cardiac myocytes (SA/AV node); increased cAMP = increased Ca

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24
Q

Elevated heart clock

A

beta-1 activation increases heart rate (SA node)

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25
Q

Buff bicep

A

beta-1 activation increases cardiac contractility (myocytes)

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26
Q

Heart hydrant

A

beta-1 activation results in increased CO

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27
Q

Open rain umbrella

A

beta-1 activation increases renin release

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28
Q

Beta-2 tuba

A

beta-2 activity

29
Q

Beta-2 camper taking big breath

A

beta-2 activation leads to broncho-dilation; increased cAMP = activates PKA

30
Q

Beta-2 camper with dilated sleeves

A

Beta-2 activation causes coronary and skeletal muscle vasodilation - decreases TPR

31
Q

Beta-2 camper with dangling DIAmond earrings

A

beta-2 activation decreases diastolic blood pressure

32
Q

Beta-2 camper roasting pig

A

beta-2 activation stimulates lipolysis and release of FFA

33
Q

Beta-2 camper producing marshmallows from liver-shaped bag

A

beta-2 activation at liver promotes gluconeogenesis

34
Q

Welcome Inside mat

A

Beta-2 activation at pancreatic islet cells promotes insulin release

35
Q

Banana peels

A

beta-2 activation can cause hypokalemia due to increased insulin

36
Q

Beta-2 camper filling eyeball balloon

A

beta-2 activation at ciliary body increases aqueous humor production

37
Q

Flannel friends

A

phenylephrine - alpha-1 agonist

38
Q

Flannel friends nasal spray

A

phenylephrine treats nasal congestion - alpha-1 mediated vasoconstriction

39
Q

Flannel friends binoculars

A

phenylephrine causes mydriasis - activates alpha-1 at pupillary dilator muscle

40
Q

Flannel friends elevated MAP

A

Phenylephrine increases MAP - alpha-1 increase in TPR; increases SBP/DBP - used in shock

41
Q

Flannel friends dangling heart watch

A

phenylephrine causes reflex bradycardia

42
Q

North Compass

A

Norepinephrine - alpha1>beta1 agonist

43
Q

North Scout blowing beta-1 bugle

A

NE has some beta-1 activity but primarily alpha agonist

44
Q

North Scout elevated MAP

A

NE increases MAP, SBP, DBP

45
Q

North Scout dangling heart watch

A

NE causes reflex bradycardia

46
Q

North Scout buff contracted bicep

A

NE increases contractility through activation of beta-1

47
Q

Septic tank

A

septic shock - phenylephrine and NE increase TPR and venous return to treat distributive/hypovolemic shock

48
Q

Just DO BUgling shirt

A

Dobutamine (beta1 > beta2)

49
Q

Just DO BUgling winding up heart flashlight

A

Dobutamine increases HR, contractility, CO

50
Q

Just DO BUgling friend’s beta-2 tuba

A

Dobutamine has beta-2 activity

51
Q

Just DO BUgling MAP

A

Dobutamine increases pulse pressure, increases SBP, decreases DBP

52
Q

Batteries out of heart flashlight

A

Dobutamine can be used in cardiogenic shock

53
Q

Iso-pro-tunnel between beta-1/beta-2 camps

A

isoproterenol - beta1/beta2 agonist

54
Q

Tunnel camper’s elevated heart watch/contracted bicep

A

Isoproterenol increases HR and contractility

55
Q

Tunnel camper’s dilated sleeves

A

isoproterenol causes vasodilation - decreases TPR

56
Q

Tunnel camper’s dangling DIAmond earrings

A

isoproterenol decreases diastolic pressure

57
Q

Tunnel between tents

A

Isoproterenol decreases MAP, decreases diastolic pressure which increases Pulse pressure

58
Q

Sleeping beta-2 counselor

A

beta-2 agonists relax uterine smooth muscle

59
Q

Do not disTURB

A

terbutaline prevents premature labor - relaxes uterus

60
Q

I dream of band camp

A

Ritodrine prevents premature labor - relaxes uterus

61
Q

Rol call sheet

A

beta-2 agonists used for bronchodilation have “rol” suffix

62
Q

Epic kiss between alpha/beta camps

A

Epinephrine - beta > alpha agonist

63
Q

Low side of Epic raft

A

Low doses - epinephrine’s beta agonist effects predominate

64
Q

Beta-2 tuba girl’s epic inhaler

A

epinephrine causes bronchodilation (beta-2)

65
Q

Epic diamond falling off low side of raft

A

low doses, epinephrine decreases diastolic pressure

66
Q

Epic elevated heart watch and buff bicep

A

epinephrine increases HR/contractility (beta-1)

67
Q

High side of raft

A

High doses of epinephrine, alpha agonist effects predominate

68
Q

High side MAP

A

Epinephrine increases systolic pressure, decrease diastolic pressure, increase MAP and increase pulse pressure

Pharm 1 (6 decks)

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