Skeletal Muscle Relaxants Flashcards
non depolarizing nmj blockers - isoquinolone derivatives
tubocurarine
mivacuium
atracurium
cisatracurium
non depolarizing nmj blockers - steroid derivatives
pancuronium
vecuronium
rocuronium
sodium gate remains closed
non depolarizing nmj
sodium gate is open but blocked
depolarizing nmj
causes laudanosine seizures
atracurium
phase 1: constant but diminished muscle response (muscle twitch)
phase 2: receptor desensitization so flaccid paralysis
Succinylcholine
blocks ryanodine recpetor
inhibit release Ca from sarco reticulum
treats malignant hyperthermia
dantrolene sodium
blocks snare protein
prevents Ach release
botulinum
gaba a
open Cl channel
diazepam
gaba b
open K channel
baclofen
A2 agonist
similar to clonidine but only reduce BP by small amount
tizanidine
release histamine
cause hypotension, flush, bronchospasm
mivacurium
atracurium
Succinylcholine
tubocurarine
