Adrenergic Agonists

Question 1

inhibits tyrosine hydroxylase

Answer 1

metyrosine

Question 2

inhibits VMAT

Answer 2

reserpine

Question 3

inhibits NET

Answer 3

cocaine

TCAs

Question 4

inhibit VAMPS and SNAPS

Answer 4

bretylium

guanethidine

Question 5

B1 = B2
vasodilator, increased CO 
decreased DAP and MAP
tx: bronchospasm, HB, Brady arrhythmias
SE: flush, angina, arrhythmias

Answer 5

isoproterenol - nonselective

Question 6

A1, A2, B1
increases TPR, DAP, SAP
+ inotropic effects on heart

Answer 6

NE

Question 7

used in cardiac arrest

hypotension

Answer 7

NE

Question 8

ADR: anxiety, palpitation, acute rise BP, headache, necrosis, gangrene, contracts uterus, severe HTN, anginal pain

Answer 8

NE

Question 9

A1, A2, B1, B2

.3 - .5 ml per 1:1000

Answer 9

Epi

Question 10

low dose: decrease TPR, DAP, MAP
medium dose: increase SBP, DAP decrease, no change MAP and no reflex HR change
high dose: vasoconstriction- MAP increase, SAP increase, DBP decrease, increase HR and decrease reflex HR

Answer 10

Epi

Question 11

ADR: restlessness, throbbing headache, tremor, cerebral hemorrhage, cardiac arrhythmias

Answer 11

Epi

Question 12

Contraindicated: hypertensives, hyperthyroid, and angina pectoris, MAOI use

Answer 12

Epi

Question 13

A1, A2, B1, B2
gains access to CNS
pseudoephedrine - OTC decongestant - cold meds
displaces NE from vesicle

Answer 13

ephedrine

Question 14

increase urine output

D1

Answer 14

dopamine

Question 15

D1
peripheral arterial dilation and naturiuresis
treats HTN - increases salt and water excretion
SE: reflex tachycardia, flush, headache, increases IOP
Contraindicated: glaucoma

Answer 15

fenoldopam

Question 16

increases release of NE

Contraindicated in patients on MAOIs - cheese rxn

Answer 16

tyramine

Question 17

increase release of NE
enters CNS
SE: anorexia, euphoria, insomnia

Answer 17

Amphetamines 
dextroamphetamines 
methylphenidate
modifinil
Methamphetamines

Question 18

treats ADHD

Answer 18

methylphenidate

Question 19

treats narcolepsy

Answer 19

modifinil

Question 20

inhibits dopamine re uptake

SE: HTN, stroke, bug crawling feeling

Answer 20

cocaine

Question 21

Direct acting A1 agonists

Answer 21

phenylephrine
methoxamine
oxymetazoline
xylometazoline

Question 22

increases BP, TPR, reflex bradycardia

A1a agonist - urinary continence

Answer 22

direct acting A1 agonists

Question 23

used to treat nasal contestant and mydriasis without cycloplegia

Answer 23

phenylephrine

Question 24

tretas paroxysomal atrial tachycardia

Answer 24

methoxamine

Question 25

used to treat topical decongestants because of their ability to promote constriction of nasal mucosal arteriole Continuous use: increase BP, HTN, destruction of nasal muscose

Answer 25

oxymetazoline | xylometazoline

Question 26

after 3 days of use: A1 - desensitized (tachyphylaxis) - loss response; B2 - dominates, causing vasodilation and rebound nasal congestion occurs

Answer 26

rebound nasal congestion

Question 27

Direct acting A2 agonists

Answer 27

clonidine methyldopa apraclodidine brimonidine

Question 28

decrease cAMP and Ca inflow; blocks release NE

Answer 28

clonidine | methyldopa

Question 29

used to treat HTN, diabetic diarrhea, narcotic addicts and to benzodiazepine withdrawal effects

Answer 29

clonidine

Question 30

SE: postural hypotension, dry mouth, sedation, rebound HTN

Answer 30

clonidine

Question 31

acts like pre synaptic A2 agonist: aqueous synthesis decrease; post synaptic A2 agonist: duct peristalsis - increase outflow treats glaucoma

Answer 31

apraclodidine | brimonidine

Question 32

Direct acting B1 agonists

Answer 32

dobutamine

Question 33

Gs action increases HR, SV, CO, BP, contractility used to treat: heart failure, septic and cardiac shock SE: tachycardia, HTN, angina, fatal arrhythmia

Answer 33

dobutamine

Question 34

Direct acting B2 agonists

Answer 34

``` albuterol salmeterol metaproterenol ritodrine terbutaline ```

Question 35

Gs action decrease TPR and BP and bronchodilation used to treat: bronchial asthma, B2 in bladder wall mediate relaxation - retention

Answer 35

albuterol salmeterol metaproterenol

Question 36

Gs action decrease TPR and BP and bronchodilation used to treat premature uterine contraction -

Answer 36

ritodrine