Adrenergic Antagonists Flashcards
non selective alpha blockers
phenoxybenzamine
phentolamine
blocks A1 and A2 causing increase of NE that then stimulates beta receptors
treatment for HTN in pheochromocytoma
phenoxybenzamine
block A1 and A2 causing reflex stimulation of SANS due to hypotension cause tachycardia
used to treat pheochromocytoma
phentolamine
selective A1 blockers
prazosin
terazosin
doxazosin
tamsulosin
A1a inactivation: relaxation of bladder trigone, prostate, urethra - increase urinary outflow, complete emptying of bladder
selective A1 blockers
used to treat essential HTN
prazosin
terazosin
doxazosin
patient loses consciousness 30-60 minutes after 1st dose > result severe postural hypotension > avoid driving and hazardous activity. admin initial dose at bed time
1st dose effect
used to treat BPH and given with finasteride
tamsulosin
selective A2 blcokers
yohimbine
mirtazapine
increase NE
aphrodisiac
SE: HTN
yohimbine
increase NE
depression
SE: increase NE at synaptic cleft in CNS
mirtazapine
non selective beta blockers
propranolol sotalol timolol carteolol with ISA nadolol penbutolol with ISA pindolol with ISA
decreases HR, CO, renin, insulin, aqueous humor secretion
causes vasoconstriction and fall in BP
propranolol
used to treat HTN, angina cardiac arrhythmias, CHF, MI, used to depress sympathetic - essential tremors, hyperthyroidism, stage fright, migraine and glaucome
propranolol
antidote for beta blockers overdose increase AC - increase cAMP; has inotropic and chronotropic effects o heart
glucagon