Skeletal Muscle Relaxants Flashcards
Neuromuscular paralysis that results from pharmacologic antagonism at the acetylcholine receptor end plate
Non depolarizing/Stabilizing Blockade
Neuromuscular paralysis that results from persistent depolarization of end plate
Depolarizing Blockade
Most rapid onset time (60-120 secs)
Rocuronium
Long acting non depolarizing neuromuscular blocker used as general anesthesia and for intubation. Notable effects includes ganglion block and recuratization. Contraindicated in MI
Tubocurarine
Short acting non depolarizing neuromuscular blockade
Mivacurium
Intermediate acting neuromuscular blockade that undergoes Hoffmann elimination
Atracurium
Undergoes elimination in the bile
Vecuronium
Rapid reversal agent for rocuronium
Sugammadex
It has a moderate block on cardiac muscarinic receptors. Used in lethal injection, euthanasia and Strychnine poisoning
Pancuronium
Druga used in Lethal Injection
Thiopental (5g), Pancuronium (100mg), Potassium Chloride (100 meq)
Mechanism of action of NDMB
Competitive antagonists at skeletal muscle nicotinic acetylcholine receptors