Drugs used in Parkinsonism

Question 0

Parkinsons disease is caused by degeneration of dopaminergic neurons in the amygdala (T/F)

Answer 0

False. It is in substancia nigra

Question 1

What are the primary signs of Parkinsons Disease

Answer 1

Remember TRAP (Tremor, Rigidity, Akinesia, Postural Instability)

Question 2

Causes of drug induced parkinsonism.

Answer 2

Typical antipsychotics, reserpine, MPTP (Methylphenyltetrahydropyridine)

Question 3

Primary Drug of choice for parkinsonism.

Answer 3

Levodopa-Carbidopa

Question 4

Levidopa-carbidopa is contraindicated in patients with known history of;

Answer 4

Psychosis

Question 5

What will happen if Levodopa is used with MAOI’s

Answer 5

Hypertensive crisis

Question 6

Deterioration of drug effect in between medication doses

Answer 6

Wearing off phenomenon

Question 7

Alternating periods of improved mobility and akinesia occuring over few hours to days during a treatment

Answer 7

On and Off Phenomenon

Question 8

Bromocriptine acts on what dopaminergic receptor?

Answer 8

Dopamine D2

Question 9

A notable side effect of bromocriptine characterized by swollen and red extremities

Answer 9

Erythromelalgia

Question 10

Used for hyperprolactinemia

Answer 10

Bromocriptine