sindrome de ictericia Flashcards

1
Q

que es

A

acumulo de pgmento biliar en el organismo por alteracion en el metabolismo de la bilirrumina

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2
Q

cuando se detecta en exploracion fisica (exclera)

A

> 2 mg/dl

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3
Q

hiperbilirrubinemia

A

sobreproduccion, transtorno emolitico, eritropoyesis ineficaz,

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4
Q

farmacos que generan hiperbillirubinemia

A

RIFAMPICINA

probenecit, ribabirina, ATAZANAVIR, indinavir

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5
Q

sindrome de gilbert

A

trastorno familiar, benigno, con aumento de BNC (<5 mg/dl). No cursa con hemólisis y la función y biopsia hepática son absolutamente normales.

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6
Q

metbaolismo de la bilirrubinal

A

1- divide en hemo y globina
2- globina – aminoacidos – reutiliza

3- hemo - divide en Fe –A hueso –> cel hematopoyeticas

  • hemo – biliverdina –> BI (antes del higado) –> BD –> intestinos –> popo y pipi
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7
Q

quien convierte el grupo hemo a biliverdina

A

enzima hemoxigenasa

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8
Q

biliverdina –> bilirrubina indirecta o no conjugada

A

enzima biliverdina reductasa

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9
Q

BI a BD

A

se une a albumina, se transporta a hepatocito, en higado se convierte BD por la GLUCORASIL TRANSFERASA (UDPG)

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10
Q

que enzima convierte BI a BD

A

GLUCORASIL TRANSFERASA (UDPG)

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11
Q

urobirilinogeno

A

1- se absorbe en color y regresa a su ciclo

2- estercobilina – elimina en popis

3- urobilina – elimina en orina

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