esteatosis hepatica Flashcards

1
Q

que es

A

Enfermedad hepática asociada a disfunción metabólica

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2
Q

epidemio

A

Hombres

genetico PNLA3 e IFNL4

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3
Q

teoria

A

resistencia a la insulina

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4
Q

sx metabolico - 3 o mas

A
  • obesidad abdominal H:>90cm, M: >80cm
  • trigl >150mg/dl,
    HDL H: <40mg/dl, M: <50
  • TA >130/85

*.Gluc >100mg/dL, DM o RI

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5
Q

fisiopatologia

A

resisitencia a la insulina –> peroxidacion de lipidos –> inflamacion –> fibrosi –> cirrosis

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6
Q

daño por neutrofilos al higado

A

cuerpos de mallory denk - depositos de grada

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7
Q

complicaciones

A

Carcinoma hepatocelular, cirrosis hepatica, transplante de higado

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8
Q

clinica - asintomatica

A

etapas avanzadas - dolor abd CSD, hepatomegalia y fatiga

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9
Q

dx

A

enzimas hepatica, PFH,

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10
Q

con que evaluas la gravedad de fibrosis

A

ecografia transabdominal

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11
Q

biopsia hepatica

A

depositos de hierro, esteatosis con inflamacion lobulillar o portal

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12
Q

inmunizaciones

A

Hepatitis A, B
Neumococo, meningococo
Influenza, Covid

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13
Q

tx

A
  • cambios en estilo de vida
  • cx bariatrica
  • omega 3
  • atorvastatina
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14
Q

tx sin comorbilidades

A

Vit E 800 Udia

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15
Q

tx con dm, fibrosis >2

A

tiazolinedionas , metformina

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