Signs and Symptoms of BTC

Question 1

Constitutional symptoms of BTC are

Answer 1

Fatigue, Anorexia, Weight Loss and Night sweats

Question 2

Obstructive Jaundice is present in_____

Answer 2

GBC and eCCA

Question 3

Pain is present in________

Answer 3

GBC, eCCA, iCCA

Question 4

May be asymptomatic

Answer 4

iCCA

Question 5

Jaundice characterized by_____

Answer 5

Yellow skin/eyes, dark yellow urine, pale stools

Question 6

Abnormal LFT values

Answer 6

eCCA

Question 7

Right Upper Abdominal pain

Answer 7

GBC

Question 8

Nausea Vomiting Weight loss

Answer 8

GBC

Question 9

BTC Tumor markers

Answer 9

CEA and CA 19-9

Question 10

LFT’s include:

Answer 10

ALT AST GGT ALP Bilirubin

Question 11

Used to guide a needle to acquire tissue for biopsy

Answer 11

Ultrasound and CT

Question 12

Evaluate bile ducts by

Answer 12

MRCP and Cholangiography (ERCP, PTC)

Question 13

PTC done if ________ cannot be done or provides insufficient info

Answer 13

ERCP

Question 14

A sample of ______ may be collected during ______ or ______

Answer 14

Bile, ERCP, PTC

Question 15

ISH detects chromosome abnormalities such as:

Answer 15

Copy number, amplification and structural alterations (gene rearrangements)

Question 16

detects SPECIFIC alteration in DNA sequences

Answer 16

PCR

Question 17

Sequence millions of DNA/RNA fragments in a single test

Answer 17

NGS

Question 18

Enables simultaneous evaluation of changes in multiple genes

Answer 18

NGS

Question 19

Assessment of molecular alterations HER2 simultaneously including ACTIVATING MUTATIONS

Answer 19

NGS

Question 20

Staging system used for BTC

Answer 20

AJCC (TNM)

Question 21

TNM staging used for _____biliary subtypes

Answer 21

4: GBC, intrahepatic, perihilar and distal bile duct tumors

Question 22

Tumor invades lamina propria or muscular layer

Answer 22

T1

Question 23

Distant Metastasis

Answer 23

M1

Question 24

Diagnosis of BTC involves:

Answer 24

Lab tests, Imaging, Molecular tests

Question 25

What evaluates ducts that are blocked narrowed or dilated?

Answer 25

Cholangiography

Question 26

Resectable BTC tumors (localized) represent _____ of all BTC’s

Answer 26

<20%

Question 27

Removal of Gall bladder

Answer 27

Cholecystectomy

Question 28

Given after surgery

Answer 28

Adjuvant Chemo or Chemoradiation

Question 29

Main treatment for unresectable, advanced or metastatic BTC is ___

Answer 29

Systemic therapy with palliative radiation and best supportive care