Module 1 BTC

Question 1

The biliary tract includes:

Answer 1

Gallbladder and Extrahepatic and Intrahepatic duct

Question 2

The extrahepatic duct includes

Answer 2

Perihilar and Distal ducts

Question 3

Biliary tract carries bile from ______

Answer 3

Liver to intestine

Question 4

Cystic duct connects_____

Answer 4

the gallbladder to the common bile duct

Question 5

iCCA’s may be grouped with_______, incidence in US is ________

Answer 5

Liver cancer (Hepatocellular), 29%

Question 6

eCCA’s may be grouped with _______, incidence in US is ______

Answer 6

GBC, 33%

Question 7

Most common BTC _______, incidence in US is _________

Answer 7

GBC, 38%

Question 8

According to SEER incidence in US is_____

Answer 8

4.4/100,000

Question 9

Mean age of BTC diagnosis is _______

Answer 9

71

Question 10

BTC is slightly more common in ______

Answer 10

women

Question 11

Incidence of iCCA is ______ between the sexes

Answer 11

Equal

Question 12

Incidence of BTC’s varies with _____

Answer 12

Subtype

Question 13

GBC and iCCA’s are most common in _______

Answer 13

Hispanics

Question 14

eCCA are most common in ________

Answer 14

Asian/Pacific Islanders, non Hispanic individuals

Question 15

A relatively small proportion of individuals with BTC are diagnosed with ________

Answer 15

localized disease

Question 16

Over ______ of patients with GBC and iCCA and ______ of patients with eCCA present with metastatic disease at diagnosis

Answer 16

1/3, nearly 1/3

Question 17

Hispanics have an incidence of GBC of _____ per 100,000 people

Answer 17

1.89

Question 18

Median OS of people diagnosed with BTC is_____

Answer 18

12 months

Question 19

The 5 year survival rates for patients with BTC are low at _______ for GBC, ______ for eCCA and _____ for iCCA

Answer 19

20%, 11%, 9%

Question 20

Survival rates differ by____

Answer 20

Diagnosis

Question 21

_______% patients initially diagnosed with distant disease expected to be alive 5 years after diagnosis

Answer 21

2-3%

Question 22

BTC risk factors share ________

Answer 22

Characteristics of Biliary tract inflammation, Structural abnormalities, Or Obstructions

Question 23

Risk factors for GBC

Answer 23

Gallstones (Cholelithiasis), Cholecystitis, Calcification of gallbladder, Polyps

Question 24

Risk factors for CCA

Answer 24

Primary Sclerosing Cholangitis (PSC),
intra hepatic bile duct stones (Hepatolithiasis), Gallstones

Cirrhosis / Liver fluke / Hep B,C, Type 2 diabetes

Question 25

GBC has _______ HER2 gene amplification or overexpression

Answer 25

19.1%

Question 26

eCCA has _____ HER2 amplification or overexpression

Answer 26

17.4%

Question 27

iCCA has ______ HER2 amplification or overexpression

Answer 27

4.8%

Question 28

iCCA has ______ FGFR2 fusion/gene rearrangements

Answer 28

9-15%

Question 29

iCCA has______IDH1 mutations

Answer 29

10-20%

Question 30

TMB-H accounts for ________

Answer 30

<5% of all BTC subtypes

Question 31

MSI-H (dMMR) accounts for ______

Answer 31

1-3% of all BTC subtypes

Question 32

MSI-H tumors are susceptible to treatment with________

Answer 32

Immune Checkpoint Inhibitors

Question 33

In some cases HER2 gene amplification leads to ___________

Answer 33

HER2 overexpression

Question 34

MSI-H critical for__________

Answer 34

repairing errors in DNA

Question 35

dMMR cells accumulate ________

Answer 35

mutations over time

Question 36

dMMR can also promote______

Answer 36

Microsatellite instability

Question 37

TMB-H describes tumors that_______

Answer 37

harbor >10 mutations per megabase of DNA