Signal Transduction Flashcards
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Charactersitics of signaling pathways
Specificity
Amplification
Desensitization
Integration
Desensitization of the cell to a ligand depends upon
Receptor down regulation
2 essential functions of receptors
Recognzing specific ligand molecules (ligand binding domain)
Transduction of signal into response (effector domain)
IP3 function
Open calcium channels
Camp function
Activate certain protein kinases
DAG
Activates certain protein kinases
Types of receptors
Ligand gated ion channels(ionotropiv)
G protein coupled receptors (metabotropic)
Enzymatic receptors(tyrosinekinase)
Receptor regulating gene expression(sterioids/transcription factors. Nuclear?)
Ligand gated ion channels respond to neurotransmitters such as
5 hydroxytryptamine(serotonin)
Glutamate
Glycine
which ach receptor is ligand gated
Nicotinic ach cholinergic receptor
The most important groups of signals that bind to receptor tyrosine kinases are
Peptide growth factors like nerve growth factor and epidermal growth factor
Peptide hormines
Ligabdz that bind and actuvate GPRCs are
Light sensitive compounds
Odors, pheromones, hormones
Neurotransmitters
Gprcs are the target of approximately how many drugs in modern medicine
40 percent
Signal transduction stages
Reception
Transduction
Response
A signal can activate…
Enzymatic activity
Genetic ttranscription
Movement of cytoskeletal components or other cell activities
Types of intracellular receptors
Cytoplasmic and nuclear
