Pharmacodynamics 1

Question 1

Study of drugs does 2 things..these are

Answer 1

Provide basis for rational therapeutic use of a drug

Design of new and superior therapeutic agents

Question 2

Macromolecular components, pathways by which drugs travel

Answer 2

Receptors, enzymes, transporters, ion channel

Question 3

Drugs interacts by

Answer 3

Disruptimg structural proteins, being enzymes, reacting chemically with small molecules, being antigens

Question 4

Receptor?

Answer 4

Macromolecular component of organism that binds and responds to endogenous chemical signals. Usually proteins that have gone post translational modifications such as covalent attachments of carbs, lipid and phosphate. Note this

Question 5

Types of receptors?

Answer 5

4. Ligand gated ion channels
   G protein coupled receptors
   Kinase linked and relayed receptors
   Nuclear receptors

Question 6

Examples of biogenic amines

Answer 6

Serotine
Dopamine
Histamine
Norepinephrine / noradrenaline

Question 7

Examples of eicoasanoids

Answer 7

Prostaglandins
Thromoboxanes
Leukotryenes