Signal hypothesis Flashcards
who proposed the signal hypothesis
Günter Blobel and David Sabatini 1971
what does the first signal hypothesis proposes?
the N terminal information guides nascent secretory polypeptide to the ER
who refined the signal hypothesis in 1975 providing competing evidenc through reconstituted assay technique
Blobel and Bernhard Dobberstein
what discovery was done about protein translocation into chloroplast in 1977
Dobberstein and Nam-Hai Chua identified a probable precursor of plant carboxylase small subunit
this confirmed port translational transport in chloroplast
who and what year was the signal recognition protein identified
Blobel and Peter Walter 1978
what did Flora Katz and Vishu Langappa demonstrated in 1978
cotranslational insertion of viral integral membrane protein into ER membrane
what significance does the sec 61 mutant hold? (1987)
it revealed components of protein conducting channels which is crucial for signal hypothesis
They suggested similar mechanism of signal hypothesis for other cellular compartments extending the hypothesis beyond ER
Tim Harrison Cesar Milstein
