Side Effects

Question 1

Amiodarone

Answer 1

Pulmonary toxicity (acute inflammatory or chronic interstitial lung disease)
Thyroid dysfunction (usually hypo)
Ocular (reversible benign corneal microdeposits)
Cardiac (can prolong QT interval, also CI in patients with 2nd or 3rd degree heart block as may cause complete heart block)

Question 2

Drugs associated with agranulocytosis

Answer 2

Clozapine
Carbimazole
Propylthiouracil

Question 3

Drugs which can cause hyperkalaemia

Answer 3

Anything inhibiting aldosterone: ACEI, ARB, K+ sparing diuretics (spironolactone and amiloride), heparin
Digoxin
Non-selective B-blockers
NSAID
Cyclosporin, tacrolimus

Question 4

Methotrexate

Answer 4

Myelosuppression (neutropenia, thrombocytopaenia, anaemia)
Hepatotoxicity
Pulmonary toxicity (not dose-dependent)