Anaesthetics

Question 1

Midazolam class

Answer 1

Benzodiazepine

Question 2

Midazolam adverse effects

Answer 2

Common: hypotension, cough, hiccup

Important but rare: arrhythmias, cardiorespiratory arrest, anaphylaxis

Question 3

Midazolam indications

Answer 3

Conscious sedation
Induction
Sedation during ventilation
Premedication
Status epilepticus

Question 4

Midazolam interactions

Answer 4

?

Question 5

Midazolam counselling

Answer 5

Responsible person must be available to take you home and look after you
Do not drive, operate machinery or engage in other hazardous activities for 24 hrs+ after anaesthesia
Do not drink alcohol during this period

Question 6

Midazolam precautions

Answer 6

Respiratory disease (including OSA)
Muscle weakness and pathology (including myasthenia gravis, muscular dystrophy, myotonias)
Renal failure
Hepatic failure
Elderly (risk of oversedation, falls, confusion, etc)
Children (can cause paradoxical excitation)

Question 7

Midazolam mechanism???

Answer 7

Potentiates inhibitory effects of GABA by increasing frequency of GABA-A channel opening

Question 8

Midazolam effects

Answer 8

Anxiolysis
Sedation
Hypnosis
Anterograde amnesia
Muscle relaxant
Antiepileptic effects