Side Effects Flashcards
Insulin
DERM: localized urticarial lesions (usually disappear), lipodystrophy of subcutaneous fat, pruritus; ENDO: hypoglycaemia due to excess; insulin resistance; OTHER: hypersensitivity reactions, incl. anaphylactic shock, angioneurotic edema
Baclofen; Skeletal Muscle Relaxant
A
Acetaminophen (Tylenol, APAP, Apsirin, etc.); Nonopioid Analgesic: p-Aminophenol, Nonsalicylate Analgesic
OTC; Preg Cat B
DERM: erythematous reactions, urticaria; HEM: anemia, leukopenia, neutropenia, pancytopenia, hemolytic anemia, methemoglobinemia (rare); HEP: jaundice
Acyclovir/ Acyclovir Sodium (Zovirax/ Zovira (Biovial)); Antiviral: Purine Nucleoside Analog
Rx; Preg Cat B
CNS: agitation, confusion, hallucinations, lethargy, tremors, seizures/coma (all systemic); CV: inflammation or phlebitis at infusion site, hypotension; DERM: burning/stinging at application site (topical), rash, hives, pruritus
Albuterol (Ventolin HFA)/ Salmeterol (Serevent Discus); Adrenergics: Bronchodilators
Rx; Preg Cat C
CNS: nervousness, restlessness, headache, insomnia; hyperactivity in children; CV: palpitations, hypertension, chest pain, angina, arrhythmias; ENDO: hyperglycemia; F/E: hyperkalemia; GI: N/V; NEURO: tremors; RESP: paradoxical bronchospasm c excessive use
Tamulosin (Flomax); Antiadrenergics
Rx; Preg Cat B
CNS: headache, dizziness, fatigue; CV: orthostatic hypotension; EENT: rhinitis, sinusitis; GI: nausea, abdominal pain, constipation, dyspepsia; GU: erectile dysfunction, diminished/retrograde ejaculation; RESP: pharyngitis, bronchitis
Alprazolam (Xanax)/ Lorazepam (Ativan); Antianxiety/Sedative-Hypnotics; Benzodiazepines
Rx; Preg Cat D
CNS: drowsiness, lethargy, dizziness, confusion, paradoxical excitement; DERM: rashes; EENT: blurry vision; GI: N/V/D, constipation, weight gain; OTHER: tolerance, physical and psychologic dependence
Amitriptyline (Generic); Tricyclic Antidepressants
Rx; Preg Cat C/D
CNS: suicidal ideations, lethargy, sedation, extrapyramidal reactions (nortriptyline); CV: arrythmias, hypotension, ECG changes; DERM: photosensitivity; EENT: blurry vision, dry eyes, dry mouth; ENDO: changes in blood glucose levels, gynecomastia; GI: constipation, hepatitis, paralytic ileum, unpleasant taste, ^ appetite and weight gain (amitriptyline); GU: urinary retention, decreased libido; HEM: blood dyscrasias
Amlodipine (Norvasc); Antihypertensive: Long Acting Calcium Channel Blocker
Rx; Preg Cat C
CNS: abnormal dreams, anxiety, dizziness, nervousness, peripheral neuropathy, hypoesthesia, tremor; CV: arrhythmias, bradycardia, chest pain, postural hypotension, peripheral schema; DERM: pruritus, rash; GI: N/V/D, anorexia, constipation, dry mouth, flatulence, gingival yperplasia; GU: micturition disorder, nocturia, sexual dysfunction; HEM: leukopenia, purpura, thrombocytopenia; MS: arthralgia, muscle cramps, myalgia; RESP: dyspnea, epistaxis; OTHER: abnormal vision, eye pain, hyperglycaemia, tinnitus, weight change
Amoxicillin (Amoxil, Trimox); Antibiotics: Penicillins (2nd Gen); Aminopenicillins
Rx; Preg Cat B
CNS: seizures c high doses; CV: edema; DERM: maculopapular rash, erythema multiforme, exfoliative dermatitis, urticaria; GI: glossitis, stomatitis, N/V/D, psuedomembranous colitis; HEM: anemia, thrombocytopenia, thrombocytopenic purpura, esoinophilia, leukopenia, agranulocytosis; HEP: ^ in serum AST; MS: athralgia; OTHER: fever, laryngeal edema, anaphylaxis, superinfection, serum sickness, crystalluria (overdose)
Aspirin (Acetylsalicyclic Acid) (Ascriptin, Bufferin, Easprin, Ecotrin, Empirin); Salicylate: Analgesic, Antiinflammatory, Antipyretic, Antiplatelet, NSAID
OTC/Rx for single ingredient formulation; Preg Cat D 1st trimester Rx Ciii; Preg Cat C 2nd and 3rd
CV: hypothrombinemia; DERM: skin rash, Stevens-Johnson syndrome, toxic epidermal necrolysis; EENT: tinnitus; GI: epigastric distress,N/V, abdominal pain, anorexia, GI bleeding; HEM: anemia, hemolysis, ^ bleeding time; HEP: hepatotxicity, ^ serum AST, ALT; OTHER: allergic reactions, incl. anaphylaxis and laryngeal edema
Atorvastatin (Lipitor)/ Pravastatin (Pravachol); HMG-CoA Reductase Inhibitors (also known as “statins”)
Rx; Preg Cat X
CNS: headache, dizziness, insomnia, weakness; CV: chest pain, peripheral edema; GI: altered taste, abdominal cramps, heartburn, N/V/D, constipation, flatus, drug-induced hepatitis, pancreatitis, ^ liver enzymes; MS: rhabdomyolisis, arthralgia, arthritis, myalgia, myositis; RESP: bronchitis; OTHER: hypersensitivity reactions
Azithromycin (Zinthromax); Antibiotics: Macrolide Antibiotics
Rx; Preg Cat B/C
CNS: dizziness, headache, somnolence, drowsiness, fatigue; CV: chest pain, palpitations, hypotension, prolonged Q-T interval (rare); DERM: Stevens-Johnson syndrome, toxic epidermal necrolysis, photosensitivity; GI: N/V/D, dyspepsia, flatulence, cholestatic jaundice, melena, pseudomembranous colitis; GU: monilia, nephritis, vaginitis; OTHER: angioedema
Lisinopril (Prinivil, Zestril); Antihypertensives, Angiotensin-Converting Enzyme Inhibitors (ACE-Is)
Rx; Preg Cat C during 1st trimester, D during 2nd/3rd trimester
CNS: headache, dizziness, mood changes, fatigue, insomnia; CV: hypotension, tachycardia, chest pain, palpitation, edema, MI (rare); DERM: flushing, rash, pruritus; ENDO: hyperuricemia; GI: taste disturbances, N/V/D, pain, dyspepsia, constipation; HEM: agranulocytosis, anemia, thrombocytosis, neutropenia (catopril only); MS: back pain, myalgia, muscle cramps; RESP: cough, dyspnea; OTHER: loss of taste, proteinuria, hyperkalemia, angioedema (enalapril and lisinopril most often)
Bupropion (Welbutrin); Antidepressant; Smoking Cessation Aid
Rx; Preg Cat B
CNS: headache, migraine, insomnia, dizziness, seizure disorders, neuropsychiatric disturbances, agitation, tremor, anxiety; CV: edema, ECG abnormalities, phlebitis (rare), tachycardia, cardiac arhythmias; DERM: rash, pruritus, dry skin, alopecia, hair colour change; EENT: visual and auditory disturbances; GI: dry mouth, N/V, constipation, anorexia, colitis (rare), bleeding; GU: nocturne, menstrual complaints, male sexual dysfunction; OTHER: weight loss, dyspnea, gynecomastia, fatigue, arthritis
Cepgalexin (Keflex); Antibiotics: Cephalosporins (1st Generation)
Rx; Preg Cat B
CNS: seizures in high doses; DERM: Stevens-Johnson syndrome, rashes, pruritus, urticaria, GI: psuedomembranous colitis, cramping, N/V/D; HEM: agranulocytosis, eosinophilia, hemolytic anemia, neutropenia, thromboytopenia; OTHER: pain at IM injection site, phlebitis at IV site, allergic reactions incl. anaphylaxis and serum sickness, superinfection
Celecoxib (Celebrex); Antiinflammatory: Cyclooxygenase-2 (COX-2) Inhibitor, NSAID
Rx; Preg Cat C
CNS: headache, dizziness, neuralgia; CV: peripheral edema, ^ hypertension, angina, tachycardia, MI (rare); DERM: alopecia, rash, photosensitivity (rare), exfoliative dermatitis (rare), Stevens-Johnson syndrome; GI: dyspepsia, abdominal pain, N/V/D, flatulence, GI bleeding, ulcers, taste changes; GU: infection, prostatic disorder, dysmenorrhea, dysuria, hematuria; HEM: thrombocytopenia (rare), anemia; RESP: pharyngitis, sinusitis, infection, dyspnea; OTHER: leg cramps, back pain, glaucoma, impaired vision, cataracts
Hydrochlorothiazide (HydroDIURIL); Diuretics (Thiazide); Antihypertensive
Rx; Preg Cat B
CNS: dizziness. vertigo, paresthesia, headache; CV: hypotension, hypercholesterolemia; DERM: purpura, urticaria, photosensitivity; EENT: blurred vision, xanthopsia; F/E: hypokalemia, hpercalcemia, hyperuricemia, hypochloremic alkalosis, hypomagnesemia, dehydration, hypovolemia; GI: anorexia, gastric irritation, N/V/D, jaundice, pancreatitis; HEM: agranulocytosis, aplastic anemia, leukopenia, thrombocytopenia; MS: fatigue, leg cramps; RESP: respiratory distress; OTHER: necrotizing angiitis
Famotidine (Pepcid)/ Ranitidine (Zantac); Histamine-2 Antagonists, Histamine-2 Blockers
Rx/OTC; Preg Cat B
CNS: confusion, dizziness, drowsiness, hallucinations, headache; CV: arrhythmias, vasculitis; ENDO: gynecomastia; GI: N/D, constipation, drug-induced hepatitis; GU: erectile dysfunction (cimetidine), decreased sperm count; HEM: agranulocytosis, aplastic anemia, anemia, neutropenia, thrombocytopenia
Ciprofloxacin (Cipro, Cipro XR, Proquin XR); Antibiotics: Fluoroquinolones
Rx; Preg Cat C
CNS: seizures, headache, insomnia, dizziness, acute psychoses, agitation, confusion, drowsiness; CV: arrhythmias (levofloxacin, moxifloxacin), prolonged Q-T interval, vasodilation; GI: N/D, abdominal pain, psuedomembranous colitis; DERM: Stevens-Johnson syndrome, rash, pruritus, urticaria; EENT: pharyngitis, rhinitis, tinitus, taste changes, visual disturbances; ENDO: hyper-/hypoglycemia; GU: vaginitis; MS: tendinitis, tendon rupture; OTHER: ^ liver function tests
Citalopram (Celexa); Antidepressants; SSRI
Rx; Preg Cat C
CNS: neuroleptic malignant syndrome, suicidal ideations, apathy, confusion, drowsiness, agitation, amnesia, anxiety; CV: postural hypotension, tachycardia; DERM: diaphoresis, photosensitivity, rash, pruritus; ENDO: weight loss/gain; F/E: hyponatremia; GI: abdominal pain, anorexia, N/D, dyspepsia, dry mouth, flatulence, altered taste, ^ saliva; GU: amenorrhea, dysmenorrhea, ejaculatory delay, erectile dysfunction, polyuria; MS: arthralgia, myalgia; NEURO: tremors, paresthesia; OTHER: serotonin syndrome, yawning, fever
Clonazepam (Klonopin); Benzodiazepine: Antiepileptic Drug
Rx Civ; Preg Cat D
CNS: drowsiness (50%), ataxia (30%), behaviour problems (25%), choreiform movements, coma, respiratory depression, hallucinations, psychosis, suicide attempts, dysarthria; CV: palpitations, ankle/facial edema; EENT: abnormal eye movement, diplopia; GI: anorexia, coated tongue, dry mouth, gastritis, nausea; HEM: anemia, leukopenia, thrombcytopenia, eosinophilia; HEP: hepatomegaly; MS: muscle weakness