Sickle Cell Disease

Question 1

The type of haemoglobin found in unborn baby is

Answer 1

HbA

Question 2

After six months, a baby has …

Answer 2

HbF

Question 3

Other types of abnormal haemoglobins include

Answer 3

HbSO, HbSC, HbSD, HbSOarab, HbSBthal

Question 4

Sickle cell is due to ….

Answer 4

The substitution of sixth amino acid glutamic acid with valine(GUG for GAG)

Question 5

Balance of deleterious and advantageous effect of a gene to maintain a constant level in the population is called

Answer 5

Balanced polymorphism

Question 6

In the pathophysiology of sicke cell disease, the events are

Answer 6

Polymerization, red cell shape change, membrane damage, vasoocclusion, haemolysis

Question 7

The union of cells into a nucleus and elongation into an insoluble fibre is called

Answer 7

Polymerization

Question 8

The survival of a sickle cell is wuthin

Answer 8

4-25 days

Question 9

The normal life cycle of RBCs is

Answer 9

3 months

Question 10

Types of sickle cell crises are

Answer 10

vaso-occlusive; hypoplastic; haemolytic ; sequestration

Question 11

Diagnostic procedures of sickle cell disease

Answer 11

Blood film test, haemoglobin electrophoresis, solubility test, FBC

Question 12

Prevention of sickle cell include

Answer 12

Infant screening, advocacy, genetic counseling, pre natal diagnosis women screening