Sickle Cell Anemia Flashcards
1
Q
Definition
A
A genetic disorder characterised by abnormal hemoglobin
2
Q
Pathophysiology
A
An HBB gene mutates, leading to production of hemoglobin S, the cause RBC to become rigid and take on a sickle shape
3
Q
It is inherited in….
A
Autosomal recessive pattern(two gene that are mutated
4
Q
Symptoms
A
Fatigue
Jaundice
Severe pain
5
Q
Complications
A
Organ damage
Vasoocclusive crises(sickle rbc cause blockage of small vessels lead to tissue ischemia
6
Q
Treatment
A
Blood transfusion
Antibiotics
Hydroxyurea therapy
Hematopoietic stem cell transplant
