Shock Flashcards
What is shock?
Severe imbalance between O2 supply and demand, leading to inadequate cellular energy production
Oxygen delivery =
CO x arterial O2 content
Name some consequences of shock
Na+/K+ ATPase dysfunction
Cellular necrosis and apoptosis
Acidemia
Endothelial dysfunction
Activation of inflammatory and coagulation cascades
MODs
Death
Three main types of shock
Circulatory
Hypoxic
Metabolic
T/F: A vast majority of shock is metabolic
False - vast majority is circulatory
What are the four types of circulatory shock?
Hypovolemic
Distributive
Obstructive
Cardiogenic
Explain the physiology of hypovolemic shock
Decreased intravascular volume
Decreased preload
Decreased CO
Name some causes of hypovolemic shock
Hemorrhage
Severe dehydration (GI, Renal)
Third space fluid loss
Severe burns
What is meant by distributive shock?
Maldistribution of fluid from changes in vascular tone and increased vascular permeability
Decreased SVR +/- Preload +/- Contractility
“We’ve got fluid in the pipes, just not where it needs to be”
How might anaphylactic shock be classified?
Distributive
Histamine-induced vasodilation
Anaphylaxis is a kind of distributive shock. What are some other causes?
Septic shock
Neurogenic shock
Pheochromocytoma or extreme fear
What is meant by obstructive shock?
Compression of heart or great vessel that interferes with venous return
Decreased diastolic filling and preload
Decreased CO
What are some causes of obstructive circulatory shock?
GDV
Obstruction of vena cava
Tension pneumothorax
Cardiac tamponade
PPV
Physiology behind cardiogenic shock
Decrease in forward flow from the heart due to “pump failure”
Primary decrease in CO
What are some causes of cardiogenic shock?
Systolic failure
Diastolic failure
AV valve degeneration of defects
Brady or tachy-arryhythmias