SHIT I CANT FUCKING REMEMBER Flashcards by Kelsey Peiser

Q

What diuretics are good for . reduced GFR?

A

Loops

Metolazone (thiazide)

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Q

What drug should you not use with K sparing diuretics?

A

ACEI/ARBs (both cause hyperkalcemia)

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Q

What drugs should you not use in pts with acute renal failure with renal a. stenosis?

A

ACEI/ARBs

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Q

What are the contraindications of B blockers?

A

End stage HF
Diabetes
Heart block (CCB)
Asthma
Variant angina (not effective)

(inhibit renin release)

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Q

What drugs increase digoxin toxicity?

A

Hypokalemia action (thiazide/loops)
Further ↓ SA/AV node activity (B-blockers)
Myocardial sensitization to digoxin
(NE-releasing agents)

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Q

What drug decrease the effectiveness of digoxin?

A

CCB

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Q

Sudden withdraw of what drug can lead to HTN crisis?

A

Clonidine

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Q

What drug inhibits clonidine?

A

TCA

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Q

What are the SE of Clonidine and methylodopa?

A

CNS effects (sedation) Xerostomia (dry mouth)

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Q

What are the SE of methylodopa?

A

Hemolytic anemia
Hepatotoxicity
Prolactin secretion

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Q

What drug is associated with 1st dose phenomenon?

A

Prazosin

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Q

What is a SE of lebetalol?

A

Hepatotoxic (why its only used in emergencies)

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Q

Reflex tachycardia, ↑ contractility
↑ Renin secretion Fluid retention
HA, flushing Palpitations, dizziness

Are effects of which drugs?

A

Vasodilators

Hydralazine, sodium nitroprusside, fenoldopam, CCB

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Q

What are SE of -dipines?

A

Enhanced development of MI

Gingival hyperplasia

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Q

What is a common SE of verapamil?

A

Constipation

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Q

What drug is associated with throbbin HA and exposure tolerance?

A

Nitroglycerin, Isosorbide dinitrate

Q

What is the only CA that is oral?

A

Acetazolamide

Q

What drugs are contraindicated in use with a PDE5 inhibitor?

A

Nitrates/nitrites
A-blockers
CYP3A4/2C9 inhibitors

Q

What are contraindications of . statins?

A

Pregnancy

Active hepatic disease Concurrent use with P450 activators or inhibitors

Q

What drug inhibits statins?

A

Gemfibrozil

Q

What drug can cause cyanide accumulation

A

Sodium nitroprusside

Q

What drug can be given in high dose for high risk ASCVD pts

A

Atorvastatin

Q

What are SE of statins?

A

↑ Aminotransferase –> Liver damage

↑ Creatine kinase –> Myopathy, muscle pain

Q

When should stains be given?

A

Evening

What drug can interfere with warfarin therapy due to its ability to cause hypoprothrombinemia from vit K malabsorption?

Cholestyramine

What hyperlipidemia drug has no effect in familial hypercholesterolemia or hypertriglyceridemia? How should it be taken?

Cholestyramine | With meals

What drug can cause cutaneous vasodilation? How can you prevent this?

Niacin | Aspirin

What drug causes the following SE: ↑ Aminotransferase ↑ Cholelithiasis, gallstones Inhibits metabolism of statins May ↑ LDL

Gemfibrozil

How are Alirocumab and Evolocumab administered?

monthly subcutaneous injections

What are SE of Class IA durgs?

``` Low therapeutic index Cardiac toxicity Blocks a receptors Torsade de pointes Diarrhea Cinchonism ```

How is lidocaine administered and why is it only useful for ventricular arrhythmias?

“Window “current is only in Purkinje/ventricles

What drug has Strong pro-arrhythmic effects?

Flecainide

What drug has the following SE Pulmonary fibrosis Deposited in tissues, cornea (yellow brown), skin (gray blue) Thyroid dysfunction

Amiodarone (oral, IV) **Prolonged QT, but no torsade de pointes

What drug will increase the effects of warfarin? decrease?

Increase- ASA | Decrease- Oral contraceptives

What drugs are contraindiated in pts with DIC or GU bleeding?

Aminocaprotic acid Tranexamic acid | Anti-fibrinolytics

What drugs should you avoid when taking Clopidogrel or Ticagrelor?

Drugs that impair CYP2C19 function (omeprazole)