SGLT 2 Side Effects And FDA

Question 1

Most common 4 side effects of it

Answer 1

UTI, female/male genital fungal disease, increased urination, hypotension

Question 2

What should be checked before initiating therapy to combat hypotension

Answer 2

Baseline BP (if low already) and GFR. Adjust diuretics and hypertensive doses

Question 3

Causes of DKA FDA warning

Answer 3

Illness, decreases food/water intake and low insulin dose

Question 4

What happens to SGLT2 for a patient on surgery

Answer 4

Hold for 3 days before surgery. Hold for four days before surgery for stegaltro

Question 5

What SGLT2 causes decreased BMD

Answer 5

Great risk for hips and spine fracture. Caution if patient has osteoporosis. Hypotension/hypovolemia May increase risk of falls for other SGLT2

Question 6

Acute kidney injury is a lab FDA warning for what drugs.

Answer 6

Dapagliflozin and Canagliflozin

Question 7

What can exercisable acute kidney injury for in plans and farxiga

Answer 7

Hypovolemia and hypotension

Question 8

What drugs can make worse AKI in involana and farxiga

Answer 8

NSAIDS, ARBs/ACEI, and diuretics

Question 9

What drug causes an FDA warning for increased foot and leg amputation and what is the caution

Answer 9

Canagliflozin. Mostly affect toes. Use with caution in patients with previous amputations, PVD, neuropathy and diabetic foot ulcers

Question 10

What FDA warning for SGLT-2 can result to a medical emergency for SGLT2

Answer 10

Fournier’s gangrene which is a serious genital lnfection