GLP1 - Agonists

Question 1

Brand name for liraglutide

Answer 1

Victoza

Question 2

Brand name for dulaglutide

Answer 2

Trulicity

Question 3

Brand name for semaglutide

Answer 3

Oxen pic and rybelsius

Question 4

Brand name for exenatide

Answer 4

Byetta. Bydureon

Question 5

Brand name for lixisenatide

Answer 5

Adylyxin

Question 6

Efficacy of GLP1

Answer 6

Reduces A1C by 0.7% to 1.6 %. Decreases weight by up to 6kg

Question 7

Advantage of GLP in terms of hypoglycemia

Answer 7

Leads to insulin release in presence of elevated glucose so it decreases chances of hypoglycemia

Question 8

How GLP1 works

Answer 8

Inhibits glucagon secretion, delays gastric emptying, decreases appetite

Question 9

GLP1 function

Answer 9

Promotes satiety which decreases appetite. Slows gastric emptying. Decease glucose output from the liver.

Question 10

If patient can afford GLP- 1 and they are on insulin. What is recommended

Answer 10

Add GLP-1

Question 11

Recommendations for GLP1 in terms of therapy

Answer 11

Recommended as initial therapy for type 2 with or at high risk for ASVD, HF, and CKD. In T2DM, it is preferred to insulin if patient can afford

Question 12

Adverse effects of GLP-1

Answer 12

Nausea and vomiting. Counter indicated in chronic pancreatitis. Counter-indicated in medullary thyroid cancer or FMH of MTC and MEN2. Avoid patients with gastroparesis. Avoid use in patients with gall bladder disease

Question 13

Advantages of tirzapeptide

Answer 13

Enhances first and second generation of insulin secretion. Reduces glucagon levels, in a glucose dependent manner. Delays gastric emptying. Increases satiety. Causes weight loss of about 11kg. Decreases by A1C by 1.5% to 2.3%

Question 14

Adverse effects of Tirzapeptide

Answer 14

N/V/D. Pancreatitis thyroid tumors. Gallbladder disease. Tachycardia

Question 15

Dosing for tirzapeptide

Answer 15

2.5 mg SQ weekly. Adjust by 0.25 mg/week increments up to 15 mg SQ weekly