DPP Inhibitors

Question 1

Brand name for sitaglipitin

Answer 1

Januvia

Question 2

Brand name for saxagliptin

Answer 2

Onglyza

Question 3

Brand name for linagliptin

Answer 3

Tradjenta

Question 4

Brand name for alogliptin

Answer 4

Nesina

Question 5

How does DPP-4 work

Answer 5

Stimulates insulin response from beta cells in glucose dependent manner. Inhibits glucagon secretion Inhibits gastric emptying. Reduces food intake and body weight

Question 6

Adverse effects of DPP-4

Answer 6

Nasopharyngitis Upper respiratory tract infections. Headache. Avoid in severe pancreatis.

Question 7

Efficacy for DPP-4 inhibitors

Answer 7

A1C decrease by 0.5 to 1%. Fbg decrease by 20 mg/dl. PPG decrease by 20-40 mg/dl. Weight decrease by 0.5kg

Question 8

FDA warnings for DPP-4

Answer 8

Joint pain. Heart failure risk