SFP: neoplasia Flashcards

1
Q

What is neoplasia

A

An abnormal mass of tissue where the growth exceeds that of normal tissue

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is meant by the term parenchyma

A

neoplastic cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

what is meant by the term stroma

A

connective tissue and vessels

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is meant by benign tumors

A

Tumors that remain localized and cannot spread to other body sites. They do, however, have risk for malignant change. Patients generally survive, but they can occasionally have significant morbidity/mortality

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is meant by malignant tumors

A

Tumors that can spread to other body sites and are capable of invasion. These tend to be associated with higher levels of morbidity/mortality

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What are adenomas

A

benign tumors of glandular tissue

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

what are lipomas

A

benign tumors of fatty cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

what are osteomas

A

benign tumors of bone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

what are papillomas

A

benign tumors with finger-like projections

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

what is a squamous papilloma

A

a benign wart

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

what is a hemangioma

A

benign tumor of mesenchymal tissue filled with blood; does not turn into malignancy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

what is a leiomyoma

A

benign lesions of smooth muscle; often seen in the uterus, GI, and lungs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

if a malignant tumor is epithelial we call it a ___

A

carcinoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

if a malignant tumor is mesenchymal, we call it a ___

A

sarcoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

what is a hamartoma

A

Mass of disorganized tissue consisting of cells and tissues normally found in the area where the hamartoma occurs; these are neoplastic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

what is a choristoma

A

congenital anomaly consisting of normal cells in an abnormal location; these are not neoplastic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

what is differentiation

A

The extent to which neoplasms resemble their cells of origin both morphologically and functionally

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

what tends to be the differentiation pattern of benign tumors

A

they tend to be well differentiated

19
Q

what is anaplasia

A

A lack of differentiation/ poorly differentiated. Blastoma is an example.

20
Q

what is dysplasia

A

disorderly proliferation; an intermediate between normal and carcinoma

21
Q

differentiate between growth characteristics of benign vs malignant lesions

A

benign lesions tend to grow and push surrounding structures to the side

malignant lesions invade surrounding tissues

22
Q

Upon microscopic examination, how do features of benign lesions compare with that of normal tissue?

A

The structural elements tend to look similar; ex: things like ducts with hold the same shapes

23
Q

Are carcinomas or sarcomas more common

A

Carcinoma; this is because epithelial cells are constantly proliferating which leads to more potential for uncoordinated growth

24
Q

Necrosis is often associated with…

A

carcinomas

25
Q

a loss of differentiation often indicates… (benign vs malignant)

A

malignant

26
Q

what is pleomorphism

A

variability of size, shape, and appearance of cells or their nuclei

27
Q

What factors predispose us to malignancy

A

environment, age, heredity, pre-neoplastic conditions

28
Q

Contrast between indirect and direct chemical carcinogens

A

Direct are substances that are cancer-causing of their own and do not require chemical transformation, while indirect require some kind of conversion in the body to be carcinogenic

29
Q

Chemotherapeutic drugs are an example of…

A

Direct chemical carcinogens

30
Q

Polycyclic hydrocarbons are an example of…

A

Indirect chemical carcinogens

31
Q

Aflatoxin B is an example of…

A

An indirect chemical carcinogen

32
Q

What are some types of radiation associated with carcinogenesis

A

UV rays, X rays, nuclear fission (nuclear bombs), and radionuclides (miners and lung cancer)

33
Q

What is cancer cachexia

A

Tumors can cause the host to lose weight without trying due to the tumors leeching resources

34
Q

Small cell carcinoma produces…

A

ACTH and ACTH-like substance, mimicking Cushing’s

35
Q

What is tumor grading

A

Determining the extent to which the architectural and cellular features of a tumor recapitulate the histology of the parent tissue

36
Q

asbestos is associated with ___

A

mesothelioma

37
Q

benzene is associated with

A

AML

38
Q

beryllium is associated with

A

lung carcinoma

39
Q

cadmium is associated with

A

prostate carcinoma

40
Q

chromium is associated with

A

lung carcinoma

41
Q

nickel is associated with

A

lung and ooropharengeal carcinoma

42
Q

radon is associated with

A

lung carcinoma

43
Q

vinyl chloride is associated with

A

hepatic angiosarcoma