Sezuires Flashcards

0
Q

Generalised sezuire

A

Involves both hemisoheres

Widespread synchronisation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
1
Q

Sezuires

A

Brief loss of conciousness
Perception of odours
Confusion
Bizare behaviours

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Types of generalised sezuires

A
Absence     
Atonic drop
Clonic
Myclonic
Generalised tonic clonic
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Absence sezuire

A

Petit mal

Brief lapse of conciousness

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Atonic drop

A

Gen
Sudden loss of posture
Brief invol muscle twitch

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Clonic

A

Repetitive jerking, 1 min

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Myoclonic

A

Single rapid twitch event

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Generalised tonic clonic

A
Grand mal
Immediate deep loss of conciousness
Tonic phase of rigid muscle contraction
Clonic phase of violent jerking 
As a consequence of focal sezuire spreading
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Focal sezuire

A

Localised synchronisation in a sezuire focus
Symptoms reflect brain area they occur in
Can become generalised

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Symptoms of focal sezuires

A

Deja vu
Temporal lobe epilepsy
Focal motor sezuires
Vulnerable brain areas=temporal lobe and motor cortex

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Jacksonian sezuire

A

Starts in fingers, travels up arm, frontal lobe epilepsy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Causes of epilepsy

A
High fever
Head injury
Stroke
Tumour
Alcohol withdrawl
Genetic abnormalisties
Development abnorm
Chronic illness

Usually due to imbalance between excitatory and inhibitory neuronal activity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What can make absence epilepsies worse?

A

Gabaa drugs

Increase synchronisation of t type ca channels in bs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Whats the general treatment for partial sezuires

A

Gaba a levels/r or na channel drugs

Decrease excitation increase inhibition

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Sodium channel inaxtivator

A

Partial sezuire treatment
Stabilises inactivated state of vg sodium channels
Reduces sustained firing of neurones
Significant side effects

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Phenytoin

A

Sodium channel inactivator

Partial sezuire treatment

16
Q

Carbamazepine

A

Sodium channel inactivator

Partial sezuire treatment

17
Q

Oxcarbazepine

A

Sodium channel inactivator

Partial sezuire treatment

18
Q

Iamotrigine

A

Sodium channel inactivator

Partial sezuire treatment

19
Q

Topiramate

A

Sodium channel inactivator

Partial sezuire treatment

20
Q

Felbamate

A

Sodium channel inactivator

Partial sezuire treatment

21
Q

Gaba a enhancers

A

Benzos , channel open for longer, engog gaba

Phenobarbital, does not need endog gaba, limited use except in status epilepticus and refractory epilepsy

Produce tollerance, sedation, confusion and dependence

22
Q

Diazepam

23
Q

Vigabatrin

A

Phenobarbital

Inhibit breakdown of gaba by gaba tansaminase

24
Tiagabine
Inhibits gaba uptake by gaba transporter
25
Gabapentin and pregabalin
Bind to gabars Decrease gaba uptake Increase gaba release Increase gaba synthesis
26
Zonisamide
Partial sezuires | Gabaa rs inhibit reuptake
27
Levitiracetam
Cyclic gaba derivative Unknown mech Bind vesicle protein sva2? Inhibiting exocytosis Bind to calcium channel to decrease neurotransmission?
28
Generalised sezuire treatment
Calcium channel blocking
29
Ethosuximide
Blocks t type ca channels that cause synchronisation in absence sezuires