Sexual Health🍆 Flashcards
What kind of bacteria is chlamydia trachomatis?
Gram negative bacteria
What are the risk factors for chlamydia infection? (3)
Under 25 Multiple sexual partners New sexual partnerA partner with other partners History of STIsUnprotected sex
What are the two types of swabs used in sexual health testing?
Charcoal swab - from endocervical or high vaginal areaNucleic acid amplification test
What is the purpose of a charcoal swab?
Allows for microscopy, culture and sensitivity
What is NAAT testing?
Checks for the DNA or RNA of the organism - Only used for chlamydia and gonorrhoea
What specimens can NAAT testing be performed on?
Low vaginal swab First catch urine - men and women Endocervical swab
What is the presentation of chlamydia? (5)
Abnormal vaginal discharge Pelvic pain Dyspareunia Dysuria Post coital bleeding Intermenstrual bleedingPenile discharge
What is the first line investigation for chlamydia?
NAAT swab
What are the differentials of chlamydia? (3)
Gonorrhoea Bacterial vaginosis Thrush Trichomonas Mycoplasma infectionPID
What is the first line management of chlamydia?
100mg doxycycline BD for 7 days
What is the first line management of chlamydia in pregnant women?
Oral Azithromycin 1g single dose
What are the complications of chlamydia infection? (5)
PID
Chronic pelvic pain
Infertility
Ectopic pregnancy
Epididymo-orchitis
Conjunctivitis
Reactive arthritis
Lymphogranuloma venereum
What are the pregnancy related complications of chlamydia? (3)
Premature delivery
Premature ROM
Low birthweight
Postpartum endometritis
Neonatal conjunctivitis
Neonatal pneumonia Chorioamnionitis
What is lymphogranuloma venereum?
A lesion affecting the lymphoid tissue around the site of infection with chlamydia Most commonly occurs in MSM
What bacteria is gonorrhoea caused by?
Neisseria gonorrhoeae
What type of bacteria is neisseria gonorrhoeae?
Gram negative diplococci
What antibiotics are many strains of gonorrhoea now resistant to?
Azithromycin and ciprofloxacin
What is the presentation of gonorrheoa infection?
Female:- Odourless purulent discharge - green or yellow - Dysuria - Pelvic pain Male:- Dysuria - Odourless purulent discharge - green or yellow - Testicular painWomen more likely to be asymptomatic
What are the risk factors for gonorrhoea infection? (3)
Age 15-24 Black ancestryCurrent/prior history of STIMultiple recent sexual partnersInconsistent condom use MSM Partner with risk factors History of sexual or physical abuse
What are the differentials of gonorrhoea? (3)
ChlamydiaTrichomonas Mycoplasma PIDCandidiasisUTI
What is the first line investigation for diagnosis of gonorrhoea?
NAAT testing (detect RNA or DNA)
Standard charcoal endocervical swab for microscopy, culture and sensitivity before initiating antibiotics
What type of swabs can be used for NAAT diagnosis of gonorrhoea?
Endocervical Urethral Vulvovaginal Rectal (MSM) Pharyngeal (MSM)
How else can gonorrhoea be diagnosed?
First catch urine
What is the first line management of gonorrhoea?
1g IM ceftriaxone
What follow up does the patient require after gonorrhoea infection?
The patient needs follow up ‘test of cure’- After 72hrs for culture - After 7 days for DNA NAAT- After 14 days for RNA NAAT
What are the complications of gonorrhoea? (3)
PID Chronic pelvic pain InfertilityConjunctivitis Epididymo-orchitis Disseminated gonorrheal infection Urethral stricture
What does disseminated gonorrheal infection cause? (3)
Non-specific skin lesions
Polyarthralgia
Migratory polyarthritis
Systemic systems - fever and fatigue
What is the key complication of gonorrhoea in a neonate?
Neonatal conjunctivitis - opthalmia neonatorum
What is bacterial vaginosis?
BV is an overgrowth of anaerobic bacteria in the vagina, and a loss of lactobacilli
What bacteria are associated with BV?
Gardnerella vaginalis (most common) Mycoplasma hominis Prevotella sp
What are the risk factors for BV? (3)
Multiple sexual partnersExcessive vaginal cleaning Recent antibioticsSmoking Copper coil
What is the presentation of BV?
Grey or white watery discharge Fishy smelling odour 50% of women are asymptomatic
What is Amsel’s criteria for BV?
3 out of 4 symptoms must be present:- Positive whiff test - fishy smell when potassium hydroxide is added - Grey or white discharge - Clue cells on microscopy - Vaginal pH > 4.5
What is the normal vaginal pH?
3.5-4.5
What are the first line investigations for BV?
Vaginal pH using swab and pH paperCharcoal vaginal swab for microscopy
What are clue cells?
Epithelial cells from the cervix that have bacteria stuck inside of them
What is the first line treatment of BV?
Asymptomatic BV does not require treatment If symptomatic:- Oral metronidazole for 5-7 days
What are the complications of BV?
Increased risk of catching STIsComplications in pregnant women:- Miscarriage - Preterm delivery - Premature ROM - Low birthweight - Chorioamnionitis
What is candidiasis?
Vaginal infection with yeast of the candida family
What is the most common organism that causes thrush?
Candida albicans
What are the risk factors for thrush? (3)
Increased oestrogen - COCPPoorly controlled diabetesImmunosuppression Broad-spectrum antibioticsHIV
What is the presentation of thrush? (3)
Non-offensive ‘cottage cheese’ discharge Vuval and vaginal itching Dysuria Superficial dyspareuniaVulval erythema
What is the first line investigation of thrush?
Usually clinically diagnosed Vaginal pH (differentiate from BV) Charcoal swab - microscopy (diagnostic)
What is the first line management of thrush?
Single oral 150mg fluconazole Single 500mg clotrimazole vaginal pessary External clotrimazole cream for vulval symptoms
What is classed as recurrent thrush?
More than 4 episodes in one year
What is the treatment of recurrent thrush?
Induction-maintenance regime - Oral fluconazole every 3 days for 3 doses- Oral fluconazole weekly for 6 months
What is the first line of candidiasis in pregnanct women?
Clotrimazole pessary - oral fluconazole is contraindicated in pregnancy
What is mycoplasma genitalium?
A bacteria that causes non-gonococcal urethritis
What is the presentation of mycoplasma genitalium? (3)
Urethritis Epididymitis Cervicitis Endometritis PID Reactive arthritis Most cases are asymptomatic
What is the first line investigation for mycoplasma genitalium?
NAAT testing First catch urine in men Vaginal swab in women (can be self taken)
What is the treatment of mycoplasma genitalium?
Doxycycline 100mg BD for 7 days then Azithromycin 1g stat and 500mg OD for 2 days
What is the treatment of mycoplasma genitalium in pregnancy?
Azithromycin alone - doxycycline is contraindicated in pregnancy
What is used as an alternative medication if mycoplasma is resistant to macrolides?
Moxifloxacin
What is trichomoniasis?
Trichomoniasis is an STI caused by the protozoa trichomonas vaginalis
What are the complications of trichomonas infection? (3)
Contracting HIV by damage to the vaginal mucosa
BV
Cervical cancer
PID
Pregnancy related complications eg preterm delivery
What is the presentation of trichomoniasis? (3)
Vaginal discharge - frothy and yellow/green Itching Dysuria Dyspareunia Balanitis - inflammation to the glans penis Strawberry cervixRaised vaginal pH
How is trichomoniasis diagnosed?
Charcoal swab with microscopy Women - posterior fornix swab, or low vaginal swab Men - First catch urine or urethral swab
What is the management of trichomoniasis?
Oral metronidazole for 5-7 daysOR 2g PO metronidazole stat
What strain of herpes virus typically causes genital herpes?
HSV-2
How can HSV-1 be contracted as genital herpes?
Through oro-genital sex
Where does the herpes virus become latent in after infection?
Sensory nerve ganglia- Trigeminal nerve ganglia in cold sores - Sacral nerve ganglia in genital herpes
What strain of herpes virus usually causes cold sores?
HSV-1
What is the presentation of genital herpes? (3)
Ulcers or blistering lesions affecting the genital areaNeuropathic pain - burning, shooting Flu-like symptoms Dysuria Inguinal lymphadenopathy
How long can symptoms last during the primary infection of genital herpes?
Up to 3 weeks
How is diagnosis of genital herpes made?
Clinical diagnosis - Ask about contacts - Can be confirmed with a viral PCR swab or NAAT testing
What measures can be used to manage the symptoms of genital herpes? (3)
Paracetamol Topical lidocaine gel Cleaning with warm salt waterAdditional oral fluids Wear loose clothing Avoid intercourse
What is the main medical treatment of genital herpes?
Oral acyclovir
What is the risk of genital herpes during pregnancy?
Risk of neonatal herpes simplex infection, which has high morbidity and mortality
How are herpes antibodies passed on from mother to baby?
The antibodies that the woman develops to the virus can pass across the placenta
What is the treatment of primary genital herpes before 28 weeks?
Initial infection treated with acyclovir
Prophylactic acyclovir started at 36 weeks gestation
Women that are asymptomatic can have a normal vaginal delivery
What is the treatment of primary genital herpes after 28 weeks
Initial infection treated with acyclovir, and prophylactic acyclovir is started immediately C-section recommended
What bacteria is syphilis caused by?
Syphilis is caused by Treponema pallidum, a spiral shaped bacteria (spirochete)
How can syphilis be contracted? (3)
Oral, vaginal or anal sexVertical transmission from mother to baby IV drug use Blood transfusion
What are the symptoms of primary syphilis?
Chancre on the genitals (lesion may not be seen in women)Non-tender lymphadenopathy
What are the symptoms of secondary syphilis? (3)
Systemic symptoms - fever, lymphadenopathy Rash on trunk, palms and soles Buccal ‘snail track’ ulcers
How long after the primary stage does secondary syphilis develop?
6-10 weeks
What is the latent stage of syphilis?
Occurs after the secondary stage - the patient becomes asymptomatic despite still being infected with syphilis