Public Health🥱 Flashcards
What is a case-control study?
A retrospective and observational study used to determine if there is an association between an exposure and a specific health outcome
What are the advantages of case-control studies? (2)
Good for rare outcomes
Quicker than cohort or intervention studies
Can investigate multiple exposures
What are the disadvantages of case-control studies? (3)
Difficulties finding controls to match with cases
Prone to selection and information bias
Cannot determine causality
Not good for rare exposures
What is a cohort study?
An epidemiological study where a group of individuals with a particular characteristic are followed up over time
What are the advantages of a cohort study? (2)
Can follow up a group with a rare exposure Good for common outcomes Can investigate multiple outcomes Less risk of selection and recall bias
What are the disadvantages of a cohort study? (2)
Takes a long time
Loss to follow up
Need a large sample size
What is a cross-sectional study?
An observational study that analyses data from a specific population at one point in time (snapshot)
What are the advantages of a cross-sectional study? (3)
Relatively cheap and quick
Provide data on prevalence at a single point in time
Large sample size
Good for surveillance and public health planning
What are the disadvantages of a cross-sectional study? (2)
Risk of reverse causality (did the exposure or outcome come first?)
Cannot measure incidence
Risk recall bias and non-response
What is a randomised controlled trial?
Subjects are randomly assigned to one of two groups - one receiving the intervention that is being tested, and one receiving an alternative (conventional) intervention
What are the advantages of a RCT? (2)
Low risk of bias and confounding
Can infer causality
What are the disadvantages of a RCT? (3)
Time consuming
Expensive
Specific inclusion/exclusion criteria may mean the study population is different from typical patients
Drop outs
What is selection bias?
A systematic error in the selection of study participants and allocation of participants to different study groups
E.g. Health studies that recruit participants directly from clinics miss all the cases who don’t attend those clinics or seek care during the study
Why does selection bias occur? (2)
Non-response
Loss to follow up
Those in an intervention group might be different in some way to those in the control group
What types of information bias are there? (4)
Measurement bias
Observer bias
Recall bias
Reporting bias
What is measurement bias?
Different equipment used to measure the outcome in the different groups
What is observer bias?
Observers expectations influence reporting
What is recall bias?
Past events not recalled correctly
What is reporting bias?
Respondants report inaccurate information because they are embarassed or feel judged
What is confounding?
A situation in which the estimate between an exposure and an outcome is distorted because of the association with another factor that is also independently associated with the outcome
What is reverse causality?
A situation when an association between an exposure and an outcome could be due to the outcome causing the exposure
What factors increase the likelihood of causality? (3)
Strength of association
Consistency of results
Dose-response association
Plausibility
Reversibility
Coherence with other information
What is the purpose of screening?
Identifying apparently well individuals who have a particular disease in order to reduce adverse outcomes
What are the disadvantages of screening? (2)
Exposure of well individuals to distressing or harmful diagnostic tests Detection and treatment of sub-clinical disease that would never have caused any problems Preventative interventions that may cause harm to the individual or population