GP👨🏽‍⚕️ Flashcards

1
Q

What are the thresholds for diagnosis of hypertension?

A

140/90 clinic BP 135/85 ambulatory BP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is the main cause of hypertension?

A

Essential hypertension - unknown cause

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What are the secondary causes of hypertension? (3)

A

ROPED R - renal failureO - obesity P - pre-eclampsiaE - endocrine D - drugs - NSAIDs, alcohol, steroids, oestrogen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is the most common cause of secondary hypertension?

A

Renal failure

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What are the risks of high blood pressure? (3)

A

Increased risk of:- Stroke - IHD - Heart failure - Left ventricular hypertrophy - Hypertensive retinopathy - Kidney failure- Vascular dementia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What is stage 1 hypertension?

A

Clinic BP >140/90 Ambulatory BP > 135/85

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is stage 2 hypertension?

A

Clinic BP > 160/100Ambulatory BP > 150/95

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is stage 3 hypertension?

A

Clinic BP > 180/120

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What investigations should all those with a new diagnosis of hypertension have? (5)

A

Urine albumin:creatinine ratio Urine dipstick HbA1cRenal function LipidsFundoscopy ECGCalculate Q riskTFTs - check for secondary causes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What medications are used in the management of hypertension?

A

Under 55:- 1st line - ACE inhibitor - 2nd line - ARB Over 55:- 1st line - calcium channel blockerBlack or afro-carribean background:- 1st line - CCB Type 2 diabetes patients - 1st line - ACE inhibitor Alternative medications:- Beta blockers + potassium sparing diuretics - 4th line - Thiazide like diuretic - 3rd line

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is malignant hypertension?

A

Hypertension above 180/120 with papilloedema

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is the treatment of malignant hypertension?

A

Same day referral for IV antihypertensives:- Sodium nitroprusside - Labetolol- GTN - Nicardipine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What lifestyle changes can patients make to manage their hypertension? (3)

A

Stop smoking Reduce alcohol intake Reduce caffeine intake Reducing dietary salt Diet and exercise

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What should be monitored in patients on antihypertensives? (3)

A

Serum electrolytes Kidney functionCheck blood pressure

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Which thiazide like diuretic is most commonly used in hypertension?

A

Indapamide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is heart failure?

A

Impaired heart function, usually of the left ventricle - blood can’t get out to the body

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What is the pathophysiology of heart failure?

A

Impaired left ventricular function resulting in blood backing up into the left ventricle and the rest of the heart The left atrium, pulmonary vein and lungs are increased in volume and pressure This results in pulmonary oedema

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

What is a normal ejection fraction?

A

Above 50%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

What is ejection fraction?

A

The proportion of blood in the left ventricle that is pumped out of the heart with each contraction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

What are the causes of heart failure? (4)

A

Ischaemic heart diseaseValvular heart disease - aortic stenosis Hypertension Arrhythmias - AFCardiomyopathy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

What is the presentation of heart failure? (5)

A

BreathlessnessCough with frothy pink/white sputumOrthopnoea Paroxysmal nocturnal dyspnoea Peripheral oedema Fatigue

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

What signs of heart failure would be seen on examination? (5)

A

TachypnoeaTachycardia Hypertension Murmurs (if caused by valvulvar heart disease)3rd heart sound Bilateral basal cracklesRaised JVPPeripheral oedema

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

What investigations are used to diagnose heart failure? (5)

A

ECGEchocardiogram BNP Bloods - LFT, TFT, U&E, FBC, lipids, HbA1c, inflammatory markersChest XR

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

What are the differentials of heart failure? (3)

A

COPD
Pulmonary fibrosis
Pneumonia
Ageing/physical inactivity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

What are the NYHA classes of heart failure?

A

Class 1 - no limitation of activity
Class 2 - comfortable at rest but symptomatic with moderate/high exertion
Class 3 - comfortable at rest but symptomatic with slight exertion
Class 4 - symptomatic at rest

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

What is the first line medical management of heart failure?

A

ACE inhibitor
Beta blocker
Aldosterone antagonist- spironolactone (if symptoms are not controlled by A+B)
Loop diuretics

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

What are haemorrhoids?

A

Enlarged anal vascular cushions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

What are the risk factors for haemorrhoids? (3)

A

Straining Constipation Pregnancy Obesity Increased age Increased intra-abdominal pressure

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

What is an anal cushion?

A

Submucosal tissue in the anus that contains connections between arteries and veins, making it very vascular

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
30
Q

What is the classification of haemorrhoids?

A

Class 1 - no prolapse
Class 2 - prolapse on straining and return on relaxation
Class 3 - prolapse on straining with no return on relaxation, but that can be pushed back
Class 4 - prolapsed permenantly

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
31
Q

What is the presentation of haemorrhoids? (3)

A

Bright red bleeding upon wiping or after opening bowels Blood not mixed with stool Sore/itchy anus Intermittent protrusion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
32
Q

What are the differentials of haemorrhoids? (3)

A

Anal fissure Crohn’s diseaseUlcerative colitis Bowel cancerAnal fistulaDiverticulosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
33
Q

What is the first line investigation of haemorrhoids?

A

Inspection and PR exam

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
34
Q

What other investigations may be performed in the diagnosis of haemorrhoids? (2)

A

FBC Colonoscopy (to exclude other conditions)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
35
Q

What is the management of haemorrhoids? (3)

A

Topical treatments - anusol Rubber band ligation Sclerotherapy Surgical treatment - haemorrhoidal artery ligation or haemorrhoidectomy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
36
Q

What is a thrombosed haemorrhoid?

A

Where there is strangulation at the base of the haemorrhoid which causes thrombosis in the haemorrhoid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
37
Q

What lifestyle advice should be given to someone with haemorrhoids?

A

More dietary fibre Good fluid intake Using laxatives where required Avoid straining

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
38
Q

What is the most effective emergency contraception?

A

Copper IUD

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
39
Q

How long after sex is a copper IUD effective for emergency contraception?

A

120 hours (5 days)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
40
Q

How does the copper IUD work?

A

It prevents implantation as it is toxic to both egg and sperm

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
41
Q

How long can a copper IUD stay in place?

A

Up to 10 years

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
42
Q

What are the contraindications to the copper IUD? (3)

A

Pregnancy Repeated history of STIs Current pelvic infection or STI Distorted uterus Abnormal cervix Unexplained bleeding Wilson’s disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
43
Q

What is the UKMEC criteria?

A

UKMEC1 - no restriction in use UKMEC2 - benefits outweigh risksUKMEC3 - risks outweigh benefits UKMEC4 - absolute contraindication

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
44
Q

What contraception should women with breast cancer avoid?

A

Any hormonal contraception - Copper IUD or barrier methods are best choice

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
45
Q

What contraception should women with Wilson’s disease avoid?

A

Copper IUD

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
46
Q

What contraception should women with cervical or endometrial cancer avoid?

A

IUS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
47
Q

What are diaphragms and cervical caps?

A

Silicone caps that fit across the cervix to prevent semen from entering the uterus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
48
Q

How is a diaphragm/cervical cap used?

A

Fitted before sex, and left in for 6 hours after sexUsed alongside spermicide gel

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
49
Q

How effective is the COCP?

A

99% with perfect use 91% with typical use

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
50
Q

How does the COCP prevent pregnancy?

A

Prevents ovulation (primary method)Progesterone thickens cervical mucus Progesterone inhibits proliferation of the endometrium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
51
Q

How does the COCP prevent ovulation?

A

Oestrogen and progesterone have negative feedback on the release of GnRH from the hypothalamus In turn, less FH and LSH is released from the anterior pituitary, without which ovulation cannot occur

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
52
Q

What are the first line choices of progesterone for the COCP?

A

Levonorgestrel or norethisterone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
53
Q

Why are levonorgestrel and norethisterone the first line choices of progesterone?

A

They have a lower VTE risk

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
54
Q

What is the first line COCP for PMS?

A

Yasmin - containing drospirenone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
55
Q

Which is the first line COCP for acne and hirtuism?

A

Dianette - containing cyprotenone acetate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
56
Q

What are the three regimes for COCP use?

A

21 days on, 7 days off 63 days on, 7 days offContinuous use

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
57
Q

What are the common side effects of the COCP? (3)

A

Unscheduled bleeding in first 3 months Breast pain and tendernessMood changes and depression Headaches

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
58
Q

What are the risks of the COCP? (3)

A

Hypertension Small increase in risk of breast cancer, and cervical cancerVTE Small risk of MI and stroke

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
59
Q

What are the contraindications to the COCP? (5)

A

Over 35 and smoking more than 15 cigarettes per day Migraine with aura History of VTEUncontrolled hypertensionIshcaemic heart diseaseHistory of vascular disease or strokeLiver cirrhosis SLE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
60
Q

What extra protection is required when starting the COCP?

A

Up to day 5 of period- no extra protection requiredDay 5 onwards - condoms for the first 7 days of pill taking

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
61
Q

What extra protection is required in the case of a missed COCP?

A

If it is less than 72 hours since the last pill taken: - Take the missed pill as soon as possible - No extra action requried

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
62
Q

What extra protection is required in the case of more than 1 missed COCP?

A

Take the missed pill as soon as possible Additional contraception needed for 7 days Day 1-7 of packet - emergency contraception neededDay 8-14 - no emergency contraception neededDay 15-21 - no emergency contraception required, but skip 7 day pill free period

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
63
Q

Can the COCP be used during a major operation?

A

No - the COCP should be stopped 4 weeks before a major operation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
64
Q

What is the only absolute contraindication to the POP?

A

Breast cancer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
65
Q

What are the two types of POP?

A

Traditional POPDesogestrel only pill

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
66
Q

What is the time window for taking the traditional POP?

A

3 hours

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
67
Q

What is the time window for taking the desogestrel only pill?

A

12 hours

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
68
Q

What is the mechanism of action of the traditional POP? (3)

A

Inhibits proliferation of the endometrium Thickens cervical mucus Reduces ciliary action in the fallopian tubes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
69
Q

What is the mechanism of action of the desogestrel only pill?

A

Inhibits ovulationInhibits proliferation of the endometrium Thickens cervical mucus Reduces ciliary action in the fallopian tubes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
70
Q

What extra protection is needed when starting the POP?

A

No extra protection needed if started on days 1-5Day 6 onwards - additional contraception required for 48 hours

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
71
Q

What are the side effects of the POP? (3)

A

Unscheduled bleeding during first three months Breast tendernessHeadaches Acne

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
72
Q

What are the risks of the POP? (2)

A

Increased risk of ovarian cystsRisk of ectopic pregnancy with traditional POPIncreased risk of breast cancer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
73
Q

What extra protection is required in the case of a missed POP pill?

A

Take the missed pill as soon as possible Use additional contraception for the next 48 hours

74
Q

How often is the progestogen-only injection given?

A

Every 12 to 13 weeks

75
Q

How long can it take for fertility to return after stopping the progestogen-only injection?

A

12 months

76
Q

What are the two types of progestogen-only injection given in the UK?

A

Depo-provera - IM injection
Sayana Press - self administered SC injection

(Medroxyprogesterone)

77
Q

What are UKMEC3 contraindications to the POP? (3)

A

Ischaemic heart disease and stroke
Liver disease
Unexplained vaginal bleeding

78
Q

What is the main mechanism of action of the depo injection?

A

Inhibits ovulation(also works by inhibiting proliferation of the endometrium and thickening cervical mucus)

79
Q

When is extra protection required when starting the depo injection?

A

No extra protection required before day 5 After day 5 - additional protection required for 7 days

80
Q

What are the side effects of the depo injection? (3)

A

Weight gain Acne Reduced libidoMood changesHeadaches Flushes Hair lossSkin reactions at injection sites

81
Q

What is the most important side effect of the depo injection?

A

Reduced bone mineral density

82
Q

What is the progestogen only implant?

A

A small 4cm plastic rod that is inserted underneath the skin, above the subcutaneous fat

83
Q

How long does the implant last for?

A

3 years

84
Q

What is the only UKMEC4 criteria for the implant?

A

Active breast cancer

85
Q

How does the implant work?

A

Inhibits ovulation Makes the endometrium less accepting of implantation Thickens cervical mucus

86
Q

What are the two types of coils?

A

IUD - copper containing coil IUS - levonorgestrel containing coil

87
Q

What are the contraindications to the coil? (3)

A

PID Immunosuppression Pregnancy Unexplained bleeding Pelvic cancerDistortion of the uterus by fibroids

88
Q

What are the risks relating to insertion of the coil? (3)

A

Bleeding Pain on insertion Vasovagal reactions Uterine perforationPIDExpulsion

89
Q

What are the types of IUS and how long can they be used for?

A

Mirena - 5 years Levosert - 5 years Kyleena - 5 years Jaydess - 3 years

90
Q

What other uses is the mirena coil licensed for?

A

Contraception, menorrhagia and HRT

91
Q

What other uses is the levosert coil licensed for?

A

Contraception and menorrhagia

92
Q

How does the IUS work?

A

Thickens cervical mucus Makes the endometrium less accepting of implantation Inhibits ovulation in some women

93
Q

What are the side effects of the IUS? (3)

A

Can cause spotting or irregular bleeding Pelvic pain Acne Headaches Breast tenderness

94
Q

What are the risks of the IUS?

A

Ectopic pregnancies Ovarian cysts

95
Q

What are the three types of emergency contraception?

A

Copper IUD Levonorgestrel (Levonelle)Ulipristal acetate (EllaOne)

96
Q

When can levonelle be taken?

A

Within 72 hours of unprotected sex

97
Q

When can EllaOne be taken?

A

Within 120 hours of unprotected sex

98
Q

What are the side effects of levonelle? (3)

A

Nausea and vomiting Spotting and changes to the next menstrual period Diarrhoea Breast tendernessDizziness Depressed mood

99
Q

What are the side effects of EllaOne? (3)

A

Nausea and vomiting Spotting and changes to the next menstrual period Back pain Mood changes Headache DizzinessBreast tenderness

100
Q

What is the Pearl Index?

A

The number of pregnancies that would be seen if 100 women used that form of contraception for one year

101
Q

At what age should a woman stop taking the COCP?

A

50 years

102
Q

When can the mirena coil or IUD be inserted after childbirth?

A

Within 48 hours of childbirth or after 4 weeks

103
Q

When can the COCP be started after childbirth?

A

After 21 daysor After 6 weeks if breastfeeding

104
Q

When can the progestogen only pill be started after childbirth?

A

Can be started at any time

105
Q

When can patients be given the copper IUD after 5 days post intercourse?

A

If the patient is up to 5 days after their earliest ovulation date

106
Q

Who should EllaOne not be given to?

A

Patients with severe asthma

107
Q

What is rheumatoid arthritis?

A

An autoimmune condition which causes chronic inflammation of the synovial lining of the joints

108
Q

Who is rheumatoid arthritis more common in?

A

3 times more common in women than in men

109
Q

What are the gene associations with rheumatoid arthritis?

A

HLA DR4HLA DR1

110
Q

What antibodies may be present in a patient with rheumatoid arthritis?

A

Rheumatoid factor Anti-CCP- more specific than RF (Anti-cyclic citrullinated peptide) antibodies

111
Q

What are the key symptoms in rheumatoid arthritis? (5)

A

Joint pain
Joint swelling
Morning stiffness < 30 minutes
Pain that gets better with exercise
Fatigue
Weight loss
Flu like illness

112
Q

Which joints are commonly affected in rheumatoid arthritis?

A

Proximal interphalangeal joints (PIP)Metacarpophalangeal joints (MCP)WristsAnklesCervical spine

113
Q

What hand signs may be present in someone with rheumatoid arthritis? (4)

A

Z thumb Swan neck deformity Boutonnieres deformity Ulnar deviation

114
Q

What are the extra-articular manifestations of rheumatoid arthritis? (3)

A

Pulmonary fibrosis Bronchiolitis obliterans Sjogren’s syndrome Anaemia of chronic diseaseCardiovascular diseaseEpiscleritis and scleritis Rheumatoid nodules

115
Q

What investigations may be carried out in the diagnosis of rheumatoid arthritis? (4)

A

Rheumatoid factorAnti-CCP antibodies CRP and ESRXR hands and feetUltrasound to confirm synovitis

116
Q

What changes may be seen on XR in someone with rheumatoid arthritis? (5)

A
117
Q

What factors are indicative of a worse prognosis of rheumatoid arthritis? (3)

A

Younger onset Male More joints and organs affectedPresence of RF and anti-CCP antibodies Erosions seen on XR

118
Q

What is the first line management of rheumatoid arthritis?

A

Monotherapy with methotrexate, leflunomide or sulfasalazine

119
Q

What is the second line management of rheumatoid arthritis?

A

Dual therapy with methotrexate, leflunomide or sulfasalazine

120
Q

What is the third line management of rheumatoid arthritis?

A

Methotrexate plus a biological therapy (usually a TNF inhibitor)

121
Q

What is the fourth line management of rheumatoid arthritis?

A

Methotrexate plus rituximab

122
Q

What anti-TNF medications are commonly used in the treatment of rheumatoid arthritis?

A

Infliximab Adalimumab Etanercept

123
Q

What is the treatment of an initial presentation or a flare up of rheumatoid arthritis?

A

A short course of glucocorticoids - prednisolone

124
Q

How is methotrexate taken for rheumatoid arthritis?

A

Methotrexate is taken orally or intramuscularlyFolic acid 5mg is given once a week, on a different day to the methotrexate

125
Q

What are the side effects of methotrexate? (3)

A

Mouth ulcersLiver toxicity Leukopenia Teratogenic

126
Q

What are the differentials of rheumatoid arthritis? (3)

A

Osteoarthritis SLEFibromyalgia Septic arthritis Psoriatic arthritis Polyarticular gout Reactive arthritis

127
Q

Which medications are safe for rheumatoid arthritis patients during pregnancy?

A

Sulfasalazine and hydroxychloroquine

128
Q

What is psoriasis?

A

A chronic inflammatory condition of the skin characterised by scaly erythematous and pruritic plaques

129
Q

What are the 5 types of psoriasis?

A

Chronic plaque psoriasis Flexural psoriasisGuttate psoriasis Pustular psoriasis Generalised psoriasis

130
Q

What is chronic plaque psoriasis?

A

Symmetrical plaques on the extensor surfaces of the limbs, scalp and back

131
Q

What is flexural psoriasis?

A

Smooth erythematous plaques without scale in flexures

132
Q

What is guttate psoriasis?

A

Multiple small, tear shaped lesions on the trunk after a streptococcal infection in children

133
Q

What is pustular psoriasis?

A

Multiple petechiae and pustules on the palms and soles

134
Q

What is generalised psoriasis?

A

Psoriasis with erythroderma and systemic illness

135
Q

What are the risk factors for psoriasis? (3)

A

Skin trauma Withdrawal of steroids Drugs - NSAIDs- Beta blockers - Lithium - Anti-malarials Stress Alcohol Smoking Cold/dry weather

136
Q

What signs are specific to psoriasis? (2)

A

Auspitz sign Koebner phenomenon Residual pigmentation after lesions resolve

137
Q

What is the auspitz sign?

A

Small points of bleeding when the plaques are scraped off

138
Q

What is the Koebner phenomenon?

A

The development of psoriatic lesions in an area of skin affected by trauma

139
Q

What is the first line topical treatment of psoriasis?

A

Topical corticosteroid and topical vitamin D applied at different times

140
Q

What is the second line topical treatment of psoriasis?

A

Stop the corticosteroid Apply topical vitamin D twice daily

141
Q

What is the third line topical treatment of psoriasis?

A

Stop topical vitamin DApply corticosteroid twice daily

142
Q

What is the first line systemic treatment of psoriasis?

A

Methotrexate

143
Q

What is the second line systemic treatment of psoriasis?

A

Ciclosporin

144
Q

What biologics can be used to treat psoriasis?

A

InfliximabEtanercept Adalimumab

145
Q

What nail changes are seen in psoriasis?

A

Nailbed pitting Onycholysis - separation of nail from nailbed Subungual hyperkeratosis - thickening of nailbed

146
Q

What is the action of metformin?

A

Increases peripheral glucose sensitivity and increases liver uptake of glucose

147
Q

What are the side effects of metformin? (3)

A

Nausea
Vomiting
Abdominal discomfort
Diarrhoea
Lactic acidosis

148
Q

What is the action of sulfonylureas? Give an example of one

A

Stimulate the pancreatic beta cells to release insulin
Glipizide

149
Q

What are the side effects of sulfonylureas? (3)

A

Hypoglycaemia Weight gain Nausea and vomiting Diarrhoea Allergic reactions

150
Q

What is the action of thiazolidinediones (glitazones)? Give an example of one.

A

Increase peripheral insulin sensitivity
Rosiglitazone/pioglitazone

151
Q

What are the side effects of thiazolidinediones?

A

Weight gain
Fluid retention and heart failure
Increased risk of fractures
Increased risk of bladder cancer

152
Q

What is the action of SLGT-2 inhibitors? Give an example of one.

A

Increase urinary glucose excretion
Empagliflozin

153
Q

What are the side effects of SLGT2 inhibitors? (3)

A

Fungal infections UTIsEuglycaemic diabetic ketoacidosis Increased risk of lower limb amputation

154
Q

What is the action of DPP-4 inhibitors? Give an example of one.

A

Inhibits the enzyme DPP-4 which breaks down incretin hormones - this leads to an increase in production of insulin
Sitagliptin

155
Q

What is atrial flutter?

A

An arrhythmia caused by a re-entrant circuit, causing the atria to contact quickly

156
Q

What heart rate is seen in atrial flutter?

A

Atrial rate of 300 bpm Ventricular rate of 150 bpm (but can be variable)

157
Q

What appearance does atrial flutter given on an ECG?

A

Sawtooth appearance

158
Q

Why can the ventricular rate be variable in atrial flutter?

A

Dependant on how many impulses from the atria conduct through to the ventricles (a 2:1 ratio would result n 150bpm, a 3:1 ratio would result in 100bpm…)

159
Q

What are the causes of atrial flutter? (3)

A

COPD Obstructive sleep apnoea Pulmonary emboli Pulmonary hypertension

160
Q

What are the symptoms of atrial flutter? (3)

A

Palpitations LightheadednessSyncope Chest pain

161
Q

What is the treatment of atrial flutter in someone haemodynamically unstable? (2)

A

Direct current synchronised cardioversion + IV amiodarone

162
Q

What is the first line management of atrial flutter?

A

Beta blocker or calcium channel blocker

163
Q

What is the second line management of atrial flutter?

A

Cardioversion

164
Q

What is atrial fibrillation?

A

Irregular and uncoordinated atrial contraction at a rate of 300-600 bpm

165
Q

What are the causes of atrial fibrillation? (3)

A

Ischaemic heart diseaseHypertension Rheumatic heart diseasePericarditis Myocarditis

166
Q

What are the symptoms of atrial fibrillation?

A

Palpitations Chest pain Shortness of breath Light headednessSyncope

167
Q

What are the signs of atrial fibrillation on ECG?

A

Irregularly irregular heartrate Absent P waves

168
Q

What is the first line management of acute atrial fibrillation in a patient that is haemodynamically unstable?

A

Synchronised DC cardioversion and amiodarone

169
Q

What is the first line management of acute atrial fibrillation in a stable patient?

A

If onset < 48 hours ago - Rate and rhythm control If more than 48 hours ago- Rate control only

170
Q

What is the management of chronic AF?

A

Rate control - 1st line - beta blocker or calcium channel blocker- 2nd line - dual therapy- Digoxin Rhythm control - Electric cardioversion - Pharmacological cardioversion

171
Q

What joint aspiration results are seen in gout?

A

Negatively birefringent needles

172
Q

What joint aspiration results are seen in pseudogout?

A

Positively birefringent rhomboid crystals

173
Q

What is the presentation of pseudogout?

A

Acute monoarthritis - Shoulder and wrist most affected

174
Q

What is the treatment of pseudogout?

A

NSAIDs (colchicine if NSAIDs are contraindicated)

175
Q

What are the causes of megaloblastic anaemia?

A

B12 deficiency Folate deficiency

176
Q

What are the causes of non-megaloblastic macrocytic anaemia? (3)

A

Liver disease Alcohol Hypothyroidism Pregnancy

177
Q

What is in the childhood 6 in 1 vaccine?

A

‘Parents Will Immunise Toddlers Because Death’

Polio
Whooping cough (pertussis)
Influenzae (haemophilus type b)
Tetanus
B (hepatitis)
Diphtheria

178
Q

What vaccines are given to children at 2, 3 and 4 months of age?

A

2 months- ‘6-1 vaccine’ (diphtheria, tetanus, whooping cough, polio, Hib and hepatitis B)
Oral rotavirus vaccine
Men B

3 months- ‘6-1 vaccine’ (diphtheria, tetanus, whooping cough, polio, Hib and hepatitis B)
Oral rotavirus vaccine
PCV (Pneumococcal Conjugate Vaccine)

4 months- ‘6-1 vaccine’ (diphtheria, tetanus, whooping cough, polio, Hib and hepatitis B)
Men B

179
Q

What childhood vaccinations are given at 12-13 months of age? (4)

A

Hib/Men C
MMR
PCV
Men B

180
Q

What vaccinations are given at 3-4 years of age?

A

‘4-in-1 pre-school booster’ (diphtheria, tetanus, whooping cough and polio)
MMR

181
Q

At what age is the HPV vaccination given to children?

A

12-13 years