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Pharm Exam 6 > Sex hormones & Gonadotropins > Flashcards

Sex hormones & Gonadotropins Flashcards

0
Q

Leuprolide

A

GnRH agonist- long acting, initial inc release then suppresses LF/FSH.
Tx: shut down HPG axis- infertility, prostate/breast ca, delay precocious puberty, endometriosis, PCOS, uterine leiomyomas
Adv: menopausal sx, testes atrophy, ovarian cyst
PROSTATE CA: use w/ antiandrogens at first!!!!

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1
Q

Gonadorelin

A

GnRH agonist, short acting, for infertility.

Not in the US

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2
Q

Nafarelin

A

GnRH agonist- long acting, initial inc release then suppresses LF/FSH.
Tx: shut down HPG axis- infertility, prostate/breast ca, delay precocious puberty, endometriosis, PCOS, uterine leiomyomas
Adv: menopausal sx, testes atrophy, ovarian cyst
PROSTATE CA: use w/ antiandrogens at first!!!!

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3
Q

Goserelin

A

GnRH agonist- long acting, initial inc release then suppresses LF/FSH.
Tx: shut down HPG axis- infertility, prostate/breast ca, delay precocious puberty, endometriosis, PCOS, uterine leiomyomas
Adv: menopausal sx, testes atrophy, ovarian cyst
PROSTATE CA: use w/ antiandrogens at first!!!!

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4
Q

Cetrorelix

A

GnRH antagonist- supp release of LH (low dose), FSH (high dose)
4-5d tx, no initial Gn surge
Tx: endometriosis, ART

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5
Q

Ganirelix

A

GnRH antagonist- supp release of LH (low dose), FSH (high dose)
4-5d tx, no initial Gn surge
Tx: endometriosis, ART

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6
Q

Urofollitropin

A

purified FSH

stim ovaries and estrogen, drives spermatogenesis

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7
Q

Follitropin-a

Follitropin-b

A

rFSH
Expensive, no urine contaminants
stim ovaries and estrogen, drives spermatogenesis

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8
Q

hMG

A

Human menopausal gonadotropins- LH+FSH but used as FSH

stim ovaries and estrogen, drives spermatogenesis

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9
Q

Menotropins

A

LH+FSH but used as FSH

stim ovaries and estrogen, drives spermatogenesis

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10
Q

hCG

A

Human chorionic gonadotropins, similar structure to LH, longet T1/2
IM admin
Sg dose to induce ovulaiton, inc Testosterone in males (up to a yr)

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11
Q

Choriogonadotropin-a

A

recombinant hCG- acts as LH
SC admin
Sg dose to induce ovulaiton, inc Testosterone in males (up to a yr)

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12
Q

Lutropin

A

Recombinant LH
Only for combo c follitropin-a (rFSH)
Sg dose to induce ovulaiton, inc Testosterone in males (up to a yr)

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13
Q

Estradiol

A

(Estrace, Estraderm)
Estrogen- endogenous
not orally active -cream/patch

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14
Q

Ethinyl estradiol

Mestranol

A

Synthetic estrogen

Combo oral contraceptives

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15
Q

Premarin

A

Conjugated estrogen - equine

HRT

16
Q

Cenestin

A

Conjugated estrogen - soy

HRT

17
Q

Diethylstilbestrol (DES)

A

Non-steroid - estrogenic activity

CI in pregnancy

18
Q

Tamoxifen

A

Estrogen agonist in uterus/bone, antagonist in breast
DOC: premenopausal estrogen dependent breast CA (prevent bone loss), no hot flash relief
Adv: risk of uterine CA, dec HDL, hot flashes, n/v
CI: thromboembolism, breast feeding

19
Q

Toremifene (Fareston)

A

Estrogen agonist in uterus/bone, antagonist in breast (tamoxifen like)
For high HDL

20
Q

Raloxifene (Evista)

A

Estrogen agonist in bone/liver, antagonist in breast/uterus
To prevent postmeno osteoporosis (inc bone density)
Adv: hot flashes, DVT, leg cramps

21
Q

Clomiphene (Clomid)

A

Estrogen antagonist in hypothalamus (inc LH/FSH, no neg feedback)
Agonist elsewhere
DOC infertility (women c intact HPG)
Adv: mltp preg, hot flashes, HA, constipation, allergic, hair loss, enlarge ovaries

22
Q

Fulvestrant (Faslodex)

A

Pure estrogen receptor agonist
For tamoxifen resistant tumors
Adv: hot flashes, GI, HA, back pain, pharyngitis

23
Q

Anastrozole (Arimidex)

Letrozole (Femara)

A

Non-steroidal comp inhibitor of aromatase (only estrogen synth inhibit)
DOC: postmeno breast CA. 2nd line: postmeno breast CA that progressed w/ tamoxifen.
Adv: menopausal sx, bone fractures, jnt pain
CI: premenopausal, pregancy

24
Q

Exemestane (Aromasin)

A

Irreversible inhibitor of aromatase (only estrogen synth inhibit)
DOC: postmeno breast CA. 2nd line: postmeno breast CA that progressed w/ tamoxifen.
Adv: menopausal sx, bone fractures, jnt pain
CI: premenopausal, pregancy

Pharm Exam 6 (8 decks)

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