Endocrine

Question 0

Cabergoline

Answer 0

DA agonist - for hyperprolactinemia from pituitary adenomas (prolactinomas)
longer T1/2, more effective, better tolerability profile than bromocriptine

Question 1

Bromocriptine

Answer 1

DA agonist - for hyperprolactinemia from pituary adenomas (prolactinomas)

Question 2

Sermorelin

Answer 2

GHRH agonist- used for dx

Geref

Question 3

Somatropin

Answer 3

GH agonist - to tx growth failure (GH def, renal disease, Turner), cachexia/Aids wasting. SC or IM daily
Adverse: edema (improves), mskl pain, hyperglycemia, hypothyroidism
CI: DM, hypothyroidism

Question 4

Somatrem

Answer 4

GH agonist - (like Somatropin w/ extra met residue)
to tx growth failure (GH def, renal disease, Turner), cachexia/Aids wasting. SC or IM daily
Adverse: edema (improves), mskl pain, hyperglycemia, hypothyroidism
CI: DM, hyporthyroidism

Question 5

Mecasermin

Answer 5

rhIGF-1 - for pt unresponsive to GH
Uses: IGF-1 deletion/mut, GH receptor mutation, GH Abs.
Adverse: hypoglycemia, cell prolif, +same as GH tx (edema, hypothyroidism)
(Increnex)

Question 6

Mecasermin rinfabate

Answer 6

rhIGF-1 & IGFBP3 (inc T1/2)
Not FDA approved yet, but better than mecasermin
(Iplex)

Question 7

Octreotide

Answer 7

Somatostatin analog (GH antagonist)
Tx: GH excess (acromegaly), Dec size of Hormone secreting tumors (VIP, carcinoid, thyrotropinomas). Tx excessive diarrhea (carcinoid)
Adverse: GI (subsides), Gallstones
Dec release of GI and pituitary hormones

Question 8

Lanreotide

Answer 8

Somatostatin analog (GH antagonist)
Tx: GH excess (acromegaly), dec tumor growth, excessive diarrhea.
Adverse: GI (subsides), gallstones/sludge

Question 9

Pegvisomant

Answer 9

GH receptor antagonist
Tx: GH excess (acromegaly), returns IGF-1 levels to normal (97%)
Adv: growth of GH secreting tumors (no feedback), hepatotoxicity
CI: hepatic disease