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Pharmacology > Sex hormones > Flashcards

Sex hormones Flashcards

1
Q

Moa of coc

A

Estrogenic suppresses fsh secretion
Progestrogenic suppresses lh secretion
Suppresses gonadotropin secretion

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2
Q

Thromboembolism is associated in excess of oral contraceptive

A

Estrogen

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3
Q

Estrogenic compound useful for postmenopausal supplementation

A

Chlorotrianesene

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4
Q

Anti androgen with moa of inhibition of androgen synthesis

A

Leuprolide

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5
Q

Anti hypertensive medication safe for pregnancy

A

Methyldopa

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6
Q

Drug used for acid peptic disease now used as abortifacient

A

Misoprostol

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7
Q

T or F: gnrh is released in pulses which is critical inhpa axis

A

True

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8
Q

Testosterone synthesis is done in which cell

A

Leydig cell

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9
Q

Testosterone binds in androgen binding protein inwhich cell

A

Sertoli cell

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10
Q

Converts androgen to estrogen

A

Aromatase

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11
Q

Hormone that associated with sertoli cell, spermatogenesis and increased abp production

A

Fsh

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12
Q

Hormone assoc with granulosa layer and increased aromatase activity

A

Fsh

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13
Q

Hormone assoc with leydig cell and testosterone production

A

Lh

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14
Q

Hormone assoc with theca cells and androgenestenedione synthesis

A

Lh

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15
Q

Effect of estrogen in basal body temperature

A

None. Progesterone has the effect of increased basal body temp

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16
Q

After ovulation, this hormone increases

A

Progesterone

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17
Q

Responsible for secretory cycle

A

Progesterone

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18
Q

T or F: after ovulation, what endometrial phase?

A

Secretory phase

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19
Q

Responsible for proliferative phase of endometrium

A

Estrogen

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20
Q

Major natural estrogen in humans

A

Estradiol

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21
Q

Synthetic estrogens

A

Ethynyl estradiol

22
Q

Non steroidal synthetic estrogen

A

Diethylstilbesterol

23
Q

Estrogen effects on bone

A

Decreases bone resorption. Prone to osteoporosis.

24
Q

Non steroidal synthetic estrogenic drug that asso with vaginal carcinoma in female offspring

A

DES.

25
Q

Stimulates growth and development of the breast alveoli during pregnancy

A

Progesterone

26
Q

Duct proliferation in breast

A

Estrogen

27
Q

Most potent natural estrogen

A

Estradiol

28
Q

Contraceptive pill that should be taken everyday at the same time

A

Progestin only pills. Benefits. Has no effect in milk production. Not prone to thrombosis

29
Q

Hot flushes. Mens irregularity, sweating, insomnia

A

Early symptoms of menopause

30
Q

Example of a selective estrogen receptor antagonist

A

Tamoxifen,

31
Q

Competitive partial aginist inhibitor of estrogen

A

Serm, tamoxifen

32
Q

Serm that is antagonistic in breast

A

Tamoxifen. Agonist in bone cardiovascular and uterus. Prone to endometrial ca.

33
Q

Apserm antagonistic to breast uterus bone and cardiovascular

A

Clomiphene. Used for ovulation induction. But with thin endometrium, might have problems in implantation.

34
Q

Pure estrogen receptor antagonist

A

Fulverstrant. PUre. FUlvestrant

35
Q

Used in inhibiting growth of estrogen dependent tumor, ex. Breast ca

A

Aromatase inhibitors. May be used as an off label ovulating agent.

36
Q

Estrogen synthesis inhibitor that Inhibits cytochrome p450 enzymes

A

Danazol

37
Q

Continues release of gnrh will result to

A

Suppresses, rather than stimulates, pituitary gonadotropin secretion. No fsh, no lh, no androgen. (Gnrh agonist)

38
Q

Ovulation induction drugs

A

Clomiphene (serm). Letrozole off label use (aromatase inhibitors)

39
Q

inhibits conversion of testosterone to dihydrotesyosterone

A

5-alpha reductase inhibitor. Finasteride. (FIve = FInasteride). Used for benign prostatic hyperplasia.

40
Q

Flutamide.

A

For prostate cancer. Androgen receptor inhibitor.

41
Q

Antifungal drug used as androgen synthesis inhibitor

A

Ketoconazole

42
Q

Progesterone receptor antagonist. Give example.

A

Mifeprestone.

43
Q

Susceptible to teratogenic effect. Period of development.

A

Embryonic period.

44
Q

Immune to teratogenic effects. Period of development

A

Pre embryonic. First 2 weeks.

45
Q

Category A drug.

A

No increased risk for fetal abnormalities, during all trimesters of pregnancy. Folic acid. Thyroid hormones

46
Q

Category D drug.

A

Fetal harm in administration BUT if needed the patient should be informed of the effects of the drug on the fetus. Benzodiazepines

47
Q

Category X. Contraindicated in pregnancy.

A

Oral contraceptive pills.

48
Q

Secreted by posterior pituitary gland and elicits milk ejection and uterine contractions

A

Oxytocin

49
Q

Ergot alkaloid that used only for control of late uterine bleeding. Not give before delivery, causes prolonged powerful uterine spasm. Used if oxytocin is not effective to control postpartum hemorrhage.

A

Methylergometrine. Methergine.

50
Q

Estrogen used in most combined oral contraceptives

A

Estradiol

Pharmacology (6 decks)

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