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Pharmacology > Endocrine pharma > Flashcards

Endocrine pharma Flashcards

1
Q

Thoanamides. Mist adverse drug reaction

A

Angranulocytosis

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2
Q

Drug of choice for hyperthyroidism

A

Methi azole

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3
Q

Used to monitor adequacy of treatment of hypothyroisim

A

Tsh

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4
Q

To monitor adequacy of hyoerthyroidism

A

Free t4

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5
Q

Most important test to in toxic nodular goiter

A

Tsh. Then if tsh is low, scan. If tsh is normal, biopsy

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6
Q

Inhibits release of preformed thyroid hormones

A

Lithium

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7
Q

Most common side effect of thionamide

A

Rash. King walang rash, pruritius.

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8
Q

Course of action to agranulocytosis sec to methimazole

A

Discontinue methimazole. Used drug from a different class.

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9
Q

level of tsh in subclinical hypothyroisdism asymptomatic that you need to treat

A

10

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10
Q

Which among glucocorticoids is long acting

A

Fluorinated derivatives. Dexa, beta, triamcinolone. No/low mineralocorticoid activity. Used in cerebral edema. Strong anti inflammatory potency. Thus can cause high blood sugar levels.

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11
Q

Quick acting glucocorticoids, needed for its mineralocorticoid potency

A

Cortisone, hydrocortisone. Low inflammatory potency.

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12
Q

Preferred glucocorticoid for opd treatment of asthma

A

Methylprednisone. Kung wala, prednisone.

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13
Q

Used for primary aldosteronism. A mineralocoticoid antagonist. Androgen antagonist, used for treatment of hirsutism, optimal effects are seen from 2 to 6 months.

A

Spironola tone

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14
Q

Problems with spironolactone

A

Can develop gynecomastia

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15
Q

Mineralocorticoid antagonist used as replacement for spironalctone in treatment of hypertension

A

Eplerenone

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16
Q

Bone resorption is stimulated by

A

Pth (constant), cortisol, thyroid hormone, prostaglandin

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17
Q

Bone formation is stimulated by

A

Pth (intermittently given), Gh, insulin, estrogen, androgen, vitamin d, calcitonin

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18
Q

Bone for ation is inhibited by which hormone

A

Cortisol

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19
Q

Bone resorption is inhibited by

A

Estrogen, androgen, calcitonin, NItric oxide

20
Q

Tretament of osteporosis. Most potent anti catabolic drug

A

Biphosphonates. Alendronante. Risendronante.

21
Q

The only true anabolic drug for treatment of osteoporosis. Most important anabolic drug for osteoporosis.

A

Pth. Teriparatide.

22
Q

Adverse effect of teriparatide. Anabolic drug for osteoporosis.

A

Osteosarcoma

23
Q

Adverse effect of bisphosphonates

A

Esophagitis (most common). Osteonecrosis (most life thretening)

24
Q

Best drug to give for pain sec to osteoporosis

A

Calcitonin

25
Q

Most ammount of calcium (carbonate or citrate)

A

Calcium carbonate

26
Q

Required calcium intake for average adult

A

1000mg/day

27
Q

Required calcium intake for elderly

A

1200 mg/day

28
Q

Rank is found in what cell

A

Osteoclast

29
Q

Rankl is found in what cell

A

Osteoblast

30
Q

First rankl inhibitor for treatment of osteoporosis.

A

Denosumab.

31
Q

T or F. Rapid acting insulins are designed to mimic endogenous insulin kinetics

A

T

32
Q

Soluble insuline. Can be mixed in iv preparations.

A

Regular and rapid acting insulin

33
Q

Insulin that is acidic

A

Glargine

34
Q

Insulin approved for pregnant women

A

Rapid short acting and intermediate

35
Q

Inhaled insulin

A

Mannkind afrezza (new drug)

36
Q

Oral anti diabetic. Incresease i sulin secretion.

A

Secretagougues. Sulfonylureas and megletinides. (SUM)

37
Q

Most potent oral anti diabetic

A

Sulfonylureas and biguanides

38
Q

Incretin

A

Intestinal secretion of insulin

39
Q

Incretin. Moa

A

Provide more glp-1. (Exenatide and liraglutide = glp-1 agonist).

40
Q

Gliptins. Moa

A

Inhibits the degradation of glp-1. Thereby increasing blood levels, increase the insulin secretion.

41
Q
  • Glifozins. Sglt-2 transporter inhibitors. Sodium glucose co transporter-2. Moa.
A

Facilitates “spilling” of glucose to the urine. Glucosuria. Glucosuria prone to urinary infection.

42
Q

Most potent sulfonylureas

A

Glibenclamide (2nd gen sulfonylurea)

43
Q

Most common adverrse drug of sulfonylurea

A

Hypoglycemia (most common). Pag wala, weight gain.

Bone marrow suppression (most life threatening)

44
Q

Drugs that causes Glucose dependent insulin sevretion

A
  • Gliptins. (Incretins)
45
Q

Drugs that causes glucagon secretion.

A

Metformin and gliptins

46
Q

Inhibi tion of peripheral conversion of t4 to t3

A

Dexamethasone, propylthiouracil. Propanolol

Pharmacology (6 decks)

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